99883-81-5Relevant academic research and scientific papers
New one-pot procedure for the synthesis of diprotected amino alcohols from unprotected vinyl aziridines
Righi, Giuliana,Bovicelli, Paolo,Tirotta, Ilaria
, p. 6439 - 6442 (2013)
An unprecedented one-pot reaction that allows the synthesis of diprotected amino alcohols from unprotected vinyl aziridines is reported. The results demonstrate the possibility to use various acyl chlorides in order to obtain differently functionalised fragments. Mechanistic insights are given.
A highly regioselective azidolysis of 2,3-epoxy amines: An unexpected [Ti(O-i-Pr)2(N3)2] mediated C-2 opening
Righi, Giuliana,Antonioletti, Roberto,Pelagalli, Romina
, p. 5582 - 5584 (2012/10/30)
The Lewis acid-catalysed regioselective azidolysis of 2,3-epoxy amines has been investigated. The results obtained demonstrated that using TMSN3 as a source of azide, the appropriate choice of Lewis acid allowed to direct the regiochemistry of the ring opening. The present methodologies provide a powerful tool in organic synthesis for the preparation of diaminoalcohol moieties.
Synthetic applications of glycidic thiolesters. Regioselective reduction to 1,3-diols and 2,3-epoxy alcohols
Liu, Hsing-Jang,Luo, Weide
, p. 128 - 134 (2007/10/02)
Glycidic thiolesters were shown to undergo regioselective reduction with Raney nickel to give 1,3-diols.With sodium borohydride at room temperature and lithium aluminum hydride at -78 deg C, the reduction of glycidic thiolesters was found to proceed chemo
