99969-17-2

Usage

Uses

Used in Organic Synthesis:
2-Amino-4-iodo-phenol is utilized as a key intermediate in organic synthesis for the production of a variety of organic compounds. Its functional groups allow for multiple reaction pathways, making it a valuable component in the creation of complex molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-Amino-4-iodo-phenol is used as a starting material or building block for the development of new drugs. The presence of the iodine atom enhances its reactivity, which can be leveraged to create novel medicinal compounds with potential therapeutic applications.
Used in Medicinal Chemistry:
2-Amino-4-iodo-phenol is employed in medicinal chemistry for the design and synthesis of pharmaceutical agents. Its unique structure allows for the exploration of new chemical space and the potential discovery of innovative treatments for various diseases and conditions.
Overall, 2-Amino-4-iodo-phenol is a significant chemical compound with a broad spectrum of applications in the fields of organic synthesis, pharmaceutical research, and medicinal chemistry, owing to its distinctive structural features and functional group versatility.

Upstream product

• 21784-73-6 4-iodo-2-nitrophenol 
• 858013-67-9 4,4'-diiodo-2,2'-azo-di-phenol 
• 2050-14-8 2,2'-Dihydroxyazobenzene 
• 119-34-6 4-amino-2-nitrophenol 
• 95-55-6 2-amino-phenol 
• 77770-09-3 3-amino-4-methyloxyphenyliodide 
• 855839-42-8 4-iodo-2,2'-azo-di-phenol 

Downstream Products

• 860584-61-8 2-(2,4-dinitro-phenoxy)-5-iodo-aniline 
• 876486-79-2 2-(2,4-dinitro-anilino)-4-iodo-phenol 
• 1146956-18-4 C₁₁H₁₄INO₃ 
• 552832-68-5 2'-hydroxy-5'-iodobenzenesulfanilide 
• 64037-13-4 5-iodo-1,3-benzoxazol-2-amine 

Relevant academic research and scientific papers

Substituent effects on the electronic structure of the flat Blatter radical: Correlation analysis of experimental and computational data

A series of C(10)-substituted derivatives of 2-Ph-3H-[1,2,4]triazino[5,6,1-kl]phenoxazin-3-yl was obtained using the aza-Pschorr, photochemical and radical-induced cyclization reactions, and through functional group transformations of the C(10)-amino and C(10)-iodo derivatives. The iodo derivative underwent Pd-catalyzed C-C cross coupling reactions leading to the installation of Ph, 2-thienyl and PhCC groups at the C(10) position effectively extending electronic conjugation. The substituent effect on the electronic properties of the 3H-[1,2,4]triazino[5,6,1-kl]phenoxazin-3-yl was investigated in twenty one derivatives with a diverse range of functional groups by spectroscopic (UV-vis and EPR) and electrochemical methods augmented with DFT calculations. Results show that the lowest energy electronic absorption and redox potentials correlate well with the σp substituent parameter, while aN hfcc and the N-H bond dissociation energy (BDE) are well described by the σm parameter. In general, increasing the electron donating ability of the C(10)-X substituent lowers the π-π?(1) excitation energy, cathodically shifts the redox potentials, increases spin delocalization beyond the [1,2,4]triazinyl ring and lowers BDE. The latter two parameters are important indicators of the overall radical stability. Molecular and crystal structures of three radicals were established with the single crystal XRD method. This journal is

Regiospecific oxyhalogenation of aromatics over SBA-15-supported nanoparticle group IV-VI metal oxides

TiOx, VOx, MoOx and WOx supported on SBA-15 exhibit efficient catalytic activity for oxyhalogenation of aromatics with the H2O2-halide ion system. Unlike the hitherto known solid catalysts, these reusable catalysts yield the para-halogenated product with 100% selectivity at 298 K and moderate acidic pH (3-5). The catalytic activity was enhanced by five orders of magnitude when supported on SBA-15. Springer Science+Business Media, LLC 2010.

COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULARY DYSTROPHY

Compounds of formula (I) wherein R1, R2, R3, R4, L1, and n are as defined herein, are useful for the treatment or prophylaxis of conditions such as Duchenne muscular dystrophy, Becker muscular dystrophy, and cachexia.

Thieme Chemistry Journal awardees - Where are they now? Synthesis of p-phenylene ethynylene based macrocycles and bimacrocycle through formation of the imine bond

This paper describes the synthesis of three monomacrocycles and one bimacrocycle from two p-phenylene ethynylene frameworks. For two of the monomacrocycles, the two frameworks were linked by an amide unit and the macrocyclization involved the intramolecular formation of one imine bond. For another monomacrocycle and the bimacrocycle, the frameworks contained two and three amino or aldehyde units, respectively, and the macrocyclization involved the intermolecular formation of two and three imine bonds. Georg Thieme Verlag Stuttgart.

Pharmaceutical compositions for CNS and other disorders

The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant α7 nicotinic receptor agonist.