99974-66-0

Basic information

• Product Name: DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE
• Synonyms: DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE;1,1-Cyclobutanedicarboxylic acid, 3-hydroxy-, 1,1-diethyl ester
• CAS NO: 99974-66-0
• Molecular Formula: C₁₀H₁₆O₅
• Molecular Weight: 216.231
• Mol File: 99974-66-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 272.939°C at 760 mmHg
• Flash Point: 97.585°C
• Appearance: /
• Density: 1.238g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: 2-8°C
• PKA: 14.23±0.40(Predicted)
• CAS DataBase Reference: DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE(99974-66-0)
• EPA Substance Registry System: DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE(99974-66-0)

Safety Data

• Hazardous Substances Data: 99974-66-0(Hazardous Substances Data)

Usage

General Description

DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE is a chemical compound belonging to the ester group, which is commonly used in the field of organic synthesis and pharmaceutical research. It is a clear, colorless liquid with a molecular formula of C12H18O6 and a molecular weight of 258.27 g/mol. DIETHYL 3-HYDROXYCYCLOBUTANE-1,1-DICARBOXYLATE is primarily utilized as an intermediate in the production of various pharmaceuticals, such as antihypertensive and anti-inflammatory drugs. It is also used as a reagent in organic chemical reactions to form new carbon-carbon bonds. Furthermore, it is important to handle this chemical with caution, as it may be harmful if swallowed, inhaled, or comes into contact with skin.

InChI:InChI=1/C10H16O5/c1-3-14-8(12)10(5-7(11)6-10)9(13)15-4-2/h7,11H,3-6H2,1-2H3

Upstream product

• 54166-15-3 diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate 
• 105-53-3 diethyl malonate 

Downstream Products

• 1415573-52-2 diethyl 3-((((benzyloxy)carbonyl)piperidin-4-yl)oxy)cyclobutane-1,1-dicarboxylate 
• 1426449-94-6 tert-butyl (3,3-difluoro-1-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)cyclobutyl)carbamate 
• 1363380-83-9 1-((tert-butoxycarbonyl)amino)-3,3-difluorocyclobutane-1-carboxylic acid 
• 1394227-82-7 C₁₈H₂₀N₂O₉S 
• 1394288-64-2 C₁₄H₁₆N₄O₉PtS 
• 1394227-83-8 C₁₄H₁₂N₂O₉S 
• 825620-41-5 diethyl 3-(p-toluenesulfonyloxy)cyclobutane-1,1-dicarboxylate 
• 1400273-68-8 1-chloro-3,3-dimethylcyclobutyl p-tolylsulfoxide 
• 1400273-67-7 3,3-dimethylcyclobutyl p-tolylsulfoxide 
• 1400273-66-6 [3-(p-tolylsulfinyl)cyclobutane-1,1-diyl]bis(methylene) dimethanesulfonate 
• 1400273-65-5 3,3-bis(hydroxymethyl)cyclobutyl p-tolylsulfoxide 
• 1400273-64-4 diethyl 3-(p-tolylsulfinyl)cyclobutane-1,1-dicarboxylate 
• 1400273-63-3 diethyl 3-(p-tolylthio)cyclobutane-1,1-dicarboxylate 
• 1352817-91-4 C₂₀H₂₈F₂N₂O₆ 

Relevant articles and documents

Synthesis and in vitro antitumour activity of carboplatin analogues containing functional handles compatible for conjugation to drug delivery systems

We describe herein the synthesis of a series of carboplatin derivatives with different functional groups at position 3 of the cyclobutane ring. This pharmacomodulation approach aims at facilitating the vectorisation of these analogues, via their subsequen

Potent anticancer activity and possible low toxicity of platinum(II) complexes with functionalized 1,1-cyclobutanedicarboxylate as a leaving ligand

Two platinum(II) complexes, DN603 and DN604, were designed and prepared by using 3-oxocyclobutane-1,1-dicarboxylate as a ligand. The compounds were prepared according to the concept that incorporation of a functionalized moiety in the leaving ligand that

Synthesis of spiro[26]nonadienones and spiro[3.6]decadienones by the reaction of cyclopropyl- and cyclobutylmagnesium carbenoids with lithium phenolates and naphtholates

Treatment of 1-chlorocyclopropyl p-tolyl sulfoxides and 1-chlorocyclobutyl p-tolyl sulfoxides with a Grignard reagent at low temperature afforded cyclopropylmagnesium carbenoids and cyclobutylmagnesium carbenoids, respectively, via a sulfoxide-magnesium e