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n-BUTYL-N-NITROSO-1-BUTAMINE

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Name

n-BUTYL-N-NITROSO-1-BUTAMINE

EINECS 213-101-1
CAS No. 924-16-3 Density 0.91 g/cm3
Solubility Melting Point
Formula C8H18 N2 O Boiling Point 250.6 °C at 760 mmHg
Molecular Weight 158.2413 Flash Point 105.3 °C
Transport Information Appearance
Safety 45-36/37-24/25-23-53 Risk Codes 22-40-63-43-36/37/38-23/24/25-46-45
Molecular Structure Molecular Structure of 924-16-3 (1-Butanamine,N-butyl-N-nitroso-) Hazard Symbols HarmfulXnToxicT
Synonyms

Dibutylamine,N-nitroso- (6CI,7CI,8CI); Di-n-butylnitrosamine; Dibutylnitrosamine;N,N-Di-n-butylnitrosamine; N,N-Dibutylnitrosamine;N-Butyl-N-nitroso-1-butanamine; N-Nitroso-N-di-n-butylamine;N-Nitrosodi-n-butylamine; N-Nitrosodibutylamine; NDBA; NSC 6830;Nitrosodibutylamine

 

n-BUTYL-N-NITROSO-1-BUTAMINE Chemical Properties

Molecular Formula:C8H18N2O
Molecular Weight:158.2413
Molecular Structure:
Density:0.91 g/cm3
Boiling Point:250.6 °C at 760 mmHg
Flash Point:105.3 °C
Alternate Names:  N-Nitrosodi-n-butylamine | NNODNBTAM
Department of N-Butyl-N-nitroso-1-butamine(924-16-3): Organics
Synonyms of N-Butyl-N-nitroso-1-butamine(924-16-3):  N-Nitroso-di-n-butylamine; N-Butyl-N-nitroso-1-butamine; Dibutylnitrosamine; Di-n-butylnitrosamine; N,N-Di-n-butylnitrosamine; N-Nitroso-di-n-butylamine;Nitrosodibutylamine

n-BUTYL-N-NITROSO-1-BUTAMINE History

N-Butyl-N-nitroso-1-butamine(924-16-3) was known Carcinogens, 8th Annual Report on Carcinogens 

n-BUTYL-N-NITROSO-1-BUTAMINE Toxicity Data With Reference

1.   

mma-esc 1 µmol/plate

   GANNA2    Gann. Japanese Journal of Cancer Research. 75 (1984),8.
2.   

dnd-esc 100 nmol/tube

   CRNGDP    Carcinogenesis. 3 (1982),781.
3.   

dns-hmn:hla 10 µmol/L

   CNREA8    Cancer Research. 38 (1978),2621.
4.   

dnd-rat:lvr 100 µmol/L

   CNREA8    Cancer Research. 42 (1982),2592.
5.   

bfa-rat-sat 158 mg/kg

   CRNGDP    Carcinogenesis. 6 (1985),967.
6.   

hma-rat-smc 2912 mg/kg

   TCMUD8    Teratogenesis, Carcinogenesis, and Mutagenesis. 3 (1983),41.
7.   

orl-ham TDLo:9 g/kg:ETA,TER

   PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 136 (1971),1007.
8.   

scu-ham TDLo:240 mg/kg:CAR,TER

   ZEKBAI    Zeitschrift fuer Krebsforschung. 86 (1976),69.
9.   

orl-rat LD50:1200 mg/kg

   NATWAY    Naturwissenschaften. 50 (1963),735.
10.   

scu-rat LD50:1200 mg/kg

   XENOBH    Xenobiotica. 3 (1973),271.
11.   

orl-ham LD50:2150 mg/kg

n-BUTYL-N-NITROSO-1-BUTAMINE Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 28 (1982),p. 151.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210)(World Health Organization, Internation Agency for Research on Cancer, ; IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 (1978),p. 51.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210)(World Health Organization, Internation Agency for Research on Cancer, ; IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 4 (1974),p. 197.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210)(World Health Organization, Internation Agency for Research on Cancer, ; Human Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 (1978),p. 51.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210)(World Health Organization, Internation Agency for Research on Cancer, . Community Right-To-Know List. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

n-BUTYL-N-NITROSO-1-BUTAMINE Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. Experimental teratogenic effects. Human mutation data reported. When heated to decomposition N-Butyl-N-nitroso-1-butamine(924-16-3) emits toxic fumes of NOx. See also NITROSAMINES.

Hazard Symbols of N-Butyl-N-nitroso-1-butamine(924-16-3): Xn T 
23:  Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) 
24:  Avoid contact with skin 
25:  Avoid contact with eyes
36:  Wear suitable protective clothing 
37:  Wear suitable gloves 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
53:  Avoid exposure - obtain special instruction before use

 

n-BUTYL-N-NITROSO-1-BUTAMINE Standards and Recommendations

DFG MAK: Animal Carcinogen, Suspected Human Carcinogen

n-BUTYL-N-NITROSO-1-BUTAMINE Analytical Methods

For occupational chemical analysis use OSHA: #27 or NIOSH: Nitrosamines 2522.

n-BUTYL-N-NITROSO-1-BUTAMINE Specification

Columbia Analytical can test for the presence of N-Butyl-N-nitroso-1-butamine(924-16-3)

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