Evaluation of Reaction Conditions for Cu-Catalyzed Tertiary Alkylation of β-Allenyl Silane a

February 22, 2024

• Title:       

   Evaluation of Reaction Conditions for Cu-Catalyzed Tertiary Alkylation of β-Allenyl Silane ^α

• Image Source:

  Copper-Catalyzed Cross-Nucleophile Coupling of β-Allenyl Silanes with Tertiary C-H Bonds: A Radical Approach to Branched 1,3-Dienes

• Mark:

  Table 1

• Associated context:

  Once determining the β-allenyl silane 1a as the model  substrate, we centered on evaluating the reaction parameters  with low-cost copper salts. Through extensive screening of  copper salts with different counterions and oxidant states  (Table 1, entries 1−6), it was found that CuBr2 showed the  best performance. Extra addition of phosphine (entry 7) or  nitrogen (entry 8) ligands did not improve the conversion.