Proteasome inhibitors containing fused γ-lactam β-lactone  bicyclic ring

February 23, 2024

• Title:       

  Proteasome inhibitors containing fused γ-lactam β-lactone bicyclic ring

• Image Source:

  2-Nitrophenyl isocyanide as a versatile convertible isocyanide: Rapid access to a fused γ-lactam β-lactone bicycle

• Mark:

  Figure 1

• Associated context:

  A fused γ-lactam ꢀ-lactone bicyclic ring system is the  common core structure found in a growing number of potent  proteasome inhibitors including omuralide (clasto-lactacystin-  ꢀ-lactone, 1),1 salinosporamides A and B (2 and 3),2 and  cinnabaramides A-C (4-6, Figure 1).3 Due to the recent  validation of proteasome inhibition as a novel therapeutic target  for cancer,4 these natural products are emerging as an important  class of drugs that offer potential new therapies.