The reaction of imidazole 1 with a slight excess of tosyl isocyanate

March 04, 2024

• Title:       

  The reaction of imidazole 1 with a slight excess of tosyl isocyanate

• Image Source:

  A new and efficient approach to the synthesis of 6-amidino-2-  oxopurines

• Mark:

  Scheme 1

• Associated context:

  The reaction of imidazole 1 with a slight excess of tosyl isocyanate was carried out under a nitrogen atmosphere. The  reagents were combined at 0 ℃ and the mixture was stirred at  room temperature for a few hours. The products 5a–e precipitated from the reaction mixture as yellow solid materials and were isolated by filtration in 85–99% yield (Scheme 1). This reaction is always accompanied by rapid colour and texture  changes, which precede the formation of the final product.