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Nepafenac CAS NO.78281-72-8

Min.Order Quantity:
100 Kilogram
Purity:
99%
Port:
China Main Port
Payment Terms:
L/C,D/A,D/P,T/T,Other

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Product Details

Keywords

  • Nepafenac
  • 78281-72-8
  • C15H14N2O2

Quick Details

  • ProName: Nepafenac
  • CasNo: 78281-72-8
  • Molecular Formula: C15H14N2O2
  • Appearance: powder
  • Application: 78281-72-8
  • DeliveryTime: Within 3-7 days
  • PackAge: Depended
  • Port: China Main Port
  • ProductionCapacity: 300 Kilogram/Month
  • Purity: 99%
  • Storage: Store in dry, dark and ventilated plac...
  • Transportation: by air or by sea
  • LimitNum: 100 Kilogram
  • Application: Multipurpose intermediate
  • Application: ISO/9001 Certificate

Superiority

nepafenac basic information
ophthalmic drugs (cataract)
product name: nepafenac
synonyms: nepafenac;2-(2-amino-3-benzoyl-phenyl)acetamide;2-amino-3-benzoylbenzeneacetamide;nepafenac,nevance;nepafanac;ahr 9434;al 6515;nevanac
cas: 78281-72-8
mf: c15h14n2o2
mw: 254.28
einecs:
product categories: amines;aromatics;intermediates & fine chemicals;isotope labelled compounds;pharmaceuticals;pharmaceutical intermediate;nevanac;other apis
mol file: 78281-72-8.mol
nepafenac structure
nepafenac chemical properties
mp 177-181°c
storage temp. refrigerator
cas database reference 78281-72-8(cas database reference)
safety information
hazard codes n
risk statements 50/53
safety statements 60-61
msds information
nepafenac usage and synthesis
ophthalmic drugs (cataract) nepafenac is a novel ophthalmic non-steroidal anti-inflammatory drug (nsaid), for the treatment of eye pain and inflammation caused by cataract surgery, compared with traditional nsaids, chemical structure of nepafenac is conducive to make it rapidly penetrate the cornea and distribute to its target site, which is helpful to reduce the accumulation of the drug in the corneal surface and to reduce the incidence of complications of the eye surface, it has many advantages such as infiltration, targeting strong, little toxic side effects and so on.
august 19, 2005 ,the us food and drug administration (fda) approved nepafenac ophthalmic suspension for the treatment of cataract surgery-related pain and inflammation, it is the first ophthalmic nsaid prodrug formulation approved for marketing.
nepafenac after ocular administration, can rapidly pass through the cornea , and under the action of eye tissue hydrolytic enzymes,it can become into ammonia diclofenac (a kind of nsaid); and ammonia diclofenac by inhibiting prostaglandin h synthase ( cyclooxygenase), can block prostaglandin synthesis to play its role as an anti-inflammatory analgesic. as is known, prostaglandin is one of the media causing ocular inflammation it can lead to blood - aqueous barrier crash, vasodilatation, increased vascular permeability and leukocyte chemotaxis, etc. in addition, prostaglandins can also control contraction of the iris sphincter through non-cholinergic mechanism which can trigger the miosis reaction during eye surgery and after surgery. after ocular administration of nsaids, it can inhibit prostaglandins synthesis in the iris, ciliary body and conjunctiva, so people can prevent eye inflammation, and reduce the associated pain.
the above information is edited by the chemicalbook of tian ye.
chemical properties light yellow solid
usage nepafenac is a non-steroidal anti-inflammatory drug (nsaid), usually sold as a prescription eye drop. it reduces pain and inflammation in the eyes. nepafenac ophthalmic is used to reduce pain and swelling after cataract surgery. its side effects may inclu
usage labelled nepafenac (n390080). a non-steroidal anti-inflammatory with analgesic activity; selective cox-2 inhibitor. prodrug of amfenac

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