Nsi-189 CAS NO.1270138-40-3 CAS NO.1270138-40-3

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nsi-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by neuralstem, inc. that was derived from pyrazine and nicotinamide. studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro. in healthy adult mice, nsi-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression. the hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.
the chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (ptsd), alzheimer’s disease, and major depressive disorder (mdd).