Sirolimus CAS NO.53123-88-9

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Min.Order Quantity:: 100 Gram

Purity:: 99%min

Port:: Shanghai,China

Payment Terms:: L/C,D/A,D/P,T/T,

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Product Details

Keywords

53123-88-9
Rapammune
Rapamycin

Quick Details

ProName: Sirolimus
CasNo: 53123-88-9
Molecular Formula: C51H79NO13
Appearance: off-white or yellow crystalline powder
Application: Metabolism Drug; Immuno-suppressant
DeliveryTime: prompt shipment
PackAge: on request
Port: Shanghai,China
ProductionCapacity: 100 Kilogram/Day
Purity: 99%min
Storage: RT.
Transportation: by sea,air
LimitNum: 100 Gram
Related Substances: ≤0.2%
Residue on Ignition: 0.1%
Heavy Metal: ≤10ppm
Valid Period: 2 years
CAS No.: 53123-88-9

Superiority

sirolimus (inn/usan), also known as rapamycin, is a macrolide produced by the bacteria streptomyces hygroscopicus. it has immunosuppressant functions in humans and is used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. it prevents activation of t cells and b cells by inhibiting their response to interleukin-2 (il-2). sirolimus is also used as a coronary stent coating. sirolimus works, in part, by eliminating old and abnormal white blood cells.[citation needed] sirolimus is effective in mice with autoimmunity and in children with a rare condition called autoimmune lymphoproliferative syndrome (alps).

Details

item	specification
appearance	odorless,off-white or yellow crystalline powder
identification a	the ir spectrum of potassium bromide preparation of the sample exhibits maxima at the same wavelengths as that of a similar preparation of in-house reference standard
identification b	the uv spectrum of 95% ethanol preparation of the sample exhibits maxima at 267nm,277nm,288nm as that of a similar preparation of in-house reference standard
identification c	the retention time of the peaks for the trans-and cis-stereoisomers in the chromatogram of assay preparation corresponds to that in the chromatogram of the standard preparation,as obtained in the assay
loss on drying	≤ 0.5%
heavy metals	≤ 0.002%
chromatographic purity
individual impurity	≤ 1.0%
total impurities	≤ 2.0%
cis-stereoisomer of sirolimus	≤ 5.0%
assay	98.0-102.0% calculated trans-and cis-stereoisomers of sirolimus on the dried basis
residual organic solvents
ethanol	≤ 5000ppm
ethyl acetate	≤ 5000ppm
acetone	≤ 5000ppm