U-73122 CAS NO.112648-68-7

u-73122的生物活性

u-73122 is an inhibitor of phospholipase c, phospholipase a2, and 5-lo (5-lipoxygenase).
ic50 value:
target: phospholipase c/a2; 5-lipoxygenase
in neutrophils and human platelets, u-73122 inhibits agonist-induced phospholipase c (ic50=1.0-2.1 μm) activation. this compound affects the phospholipases by inhibiting the hydrolysis of ppi (phosphatidylinositol) to ip3 (inositol triphosphate), which in turn leads to a drop in cytosolic ca2+. in sk-n-sh neuroblastoma cells, u-73122 inhibits agonist-induced down-regulation of muscarinic receptors. in addition, it is a useful tool to investigate receptor-mediated pi turnover in signal transduction. u-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (ic50 = 50 nm) as well as adhesion-dependent granule exocytosis and oxidative burst. u-73122 is useful as a negative control for investigations of u-73122 phospholipase c antagonism and its cellular consequences.