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| CAS No.: | 74863-84-6 |
|---|---|
| Name: | Argatroban |
| Molecular Structure: | |
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|
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| Formula: | C23H36N6O5S |
| Molecular Weight: | 508.642 |
| Synonyms: | 2-Piperidinecarboxylicacid,1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-,[2R-[1(2S*),2a,4b]]-[partial]-;Acova;Argatra;Argipidin;Argipidine;DK 7419;GN 1600;MCI 9038;MD 805;MQPA;Novastan;OM 805;Slonnon; |
| EINECS: | 638-764-8 |
| Density: | 1.47 g/cm3 |
| Melting Point: | 188-189 °C |
| Boiling Point: | 801.3 °C at 760 mmHg |
| Flash Point: | 438.4 °C |
| Appearance: | white to off-white crystalline solid |
| Hazard Symbols: |
 Xn, N
|
| Risk Codes: | R20/21/22; R51/53 |
| PSA: | 186.09000 |
| LogP: | 3.65110 |
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(2R,4R)-1-[NG-nitro-N2-(3-methyl-8-quinolinesulphonyl)-L-arginyl]-4-methyl-2-piperidine carboxylic acid
- 74863-84-6
argatroban
| Conditions | Yield |
|---|---|
| With hydrogen; 5%-palladium/activated carbon In methanol; acetic acid at 85℃; under 6375.64 Torr; for 8h; Product distribution / selectivity; | 93% |
| With palladium on activated charcoal; hydrogen; acetic acid In ethanol under 760.051 Torr; |
- 367952-84-9
C30H37N7O7S
- 74863-84-6
argatroban
| Conditions | Yield |
|---|---|
| With hydrogen; palladium on activated charcoal In ethanol; acetic acid at 20℃; under 760 Torr; for 20h; | 90% |
- 74863-84-6
argatroban
| Conditions | Yield |
|---|---|
| With palladium 10% on activated carbon; hydrogen; acetic acid In ethanol at 20℃; under 760.051 Torr; for 16h; | 88% |
- 626-58-4
4-methylpiperidin
- 74863-84-6
argatroban
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1.1: 100 percent / Et3N / CH2Cl2 / 0 - 20 °C 2.1: s-BuLi; TMEDA / diethyl ether / -90 °C 2.2: 35 percent / diethyl ether / -90 - 20 °C 3.1: 99 percent / HCl / ethyl acetate / 0 - 20 °C 4.1: 100 percent / HCl / ethyl acetate / 20 °C 5.1: 86 percent / Et3N / CH2Cl2 / 0 °C 6.1: 90 percent / H2 / 10 percent Pd/C / ethanol; acetic acid / 20 h / 20 °C / 760 Torr View Scheme |
- 123387-50-8
4-methylpiperidine-1-carboxylic acid tert-butyl ester
- 74863-84-6
argatroban
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1.1: s-BuLi; TMEDA / diethyl ether / -90 °C 1.2: 35 percent / diethyl ether / -90 - 20 °C 2.1: 99 percent / HCl / ethyl acetate / 0 - 20 °C 3.1: 100 percent / HCl / ethyl acetate / 20 °C 4.1: 86 percent / Et3N / CH2Cl2 / 0 °C 5.1: 90 percent / H2 / 10 percent Pd/C / ethanol; acetic acid / 20 h / 20 °C / 760 Torr View Scheme |
- 74863-84-6
argatroban
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: Et3N / -35 °C 2: 100 percent / HCl / ethyl acetate / 20 °C 3: 86 percent / Et3N / CH2Cl2 / 0 °C 4: 90 percent / H2 / 10 percent Pd/C / ethanol; acetic acid / 20 h / 20 °C / 760 Torr View Scheme |
- 74863-82-4
8-(chlorosulphonyl)-3-methylquinoline
- 74863-84-6
argatroban
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 86 percent / Et3N / CH2Cl2 / 0 °C 2: 90 percent / H2 / 10 percent Pd/C / ethanol; acetic acid / 20 h / 20 °C / 760 Torr View Scheme |
- 74863-84-6
argatroban
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 100 percent / HCl / ethyl acetate / 20 °C 2: 86 percent / Et3N / CH2Cl2 / 0 °C 3: 90 percent / H2 / 10 percent Pd/C / ethanol; acetic acid / 20 h / 20 °C / 760 Torr View Scheme |
- 74863-84-6
argatroban
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 99 percent / HCl / ethyl acetate / 0 - 20 °C 2: 100 percent / HCl / ethyl acetate / 20 °C 3: 86 percent / Et3N / CH2Cl2 / 0 °C 4: 90 percent / H2 / 10 percent Pd/C / ethanol; acetic acid / 20 h / 20 °C / 760 Torr View Scheme |
- 74863-84-6
argatroban
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 100 percent / HCl / ethyl acetate / 20 °C 2: 86 percent / Et3N / CH2Cl2 / 0 °C 3: 90 percent / H2 / 10 percent Pd/C / ethanol; acetic acid / 20 h / 20 °C / 760 Torr View Scheme |
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History
In 2000, argatroban(74863-84-6) was licensed by the Food and Drug Administration (FDA) for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). In 2002, it was approved for use during percutaneous coronary interventions in patients who have HIT or are at risk for developing it.
Specification
The IUPAC name of Argatroban is (2R,4R)-1-[5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid. With the CAS registry number 74863-84-6, it is also named as 2-Piperidinecarboxylic acid, 1-(5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-. The product's categories are Intermediates & Fine Chemicals; Pharmaceuticals. It is white to off-white crystalline solid.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 2.56; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): -0.43; (4)ACD/LogD (pH 7.4): -0.45; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.02; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 11; (10)#H bond donors: 7; (11)#Freely Rotating Bonds: 8; (12)Index of Refraction: 1.674; (13)Molar Refractivity: 129.78 cm3; (14)Molar Volume: 345.7 cm3; (15)Polarizability: 51.45×10-24 cm3; (16)Surface Tension: 61.6 dyne/cm; (17)Enthalpy of Vaporization: 122.18 kJ/mol; (18)Vapour Pressure: 4.23E-27 mmHg at 25°C; (19)Rotatable Bond Count: 9; (20)Tautomer Count: 2; (21)Exact Mass: 508.246789; (22)MonoIsotopic Mass: 508.246789; (23)Topological Polar Surface Area: 189; (24)Heavy Atom Count: 35; (25)Complexity: 887.
Preparation of Argatroban: It can be obtained by the following reaction.
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this product
Uses of Argatroban: It is used as an anticoagulant in individuals with thrombosis and heparin induced thrombocytopenia. The combination of argatroban and warfarin may raise the INR to greater than 5.0 without a significant increased risk of bleeding complications.
People can use the following data to convert to the molecule structure.
1. SMILES:O=C(O)[C@@H]3N(C(=O)C(NS(=O)(=O)c1cccc2c1NCC(C2)C)CCC/N=C(\N)N)CC[C@@H](C)C3
2. InChI:InChI=1/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26)/t14-,15,17,18-/m1/s1