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| CAS No.: | 11115-82-5 |
|---|---|
| Name: | ENDURACIDIN HYDROCHLORIDE |
| Molecular Structure: | |
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| Formula: | Unspecified |
| Molecular Weight: | 2340.2677 |
| Synonyms: | Enramycin;Enradin; |
| Melting Point: | 238-245 °C (decomp) |
| PSA: | 922.33000 |
| LogP: | 3.83560 |
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The Enduracidin, with the CAS registry number 11115-82-5, is also known as Enduracidin. It belongs to the product categories of medicines and drugs.This chemical's molecular formula is C107H140Cl2N26O32. What's more,Its systematic name is Enduracidin.Its storage temperature is 20°C.And it is Poison by intravenous route.Moderately toxic by intraperitoneal route.The Enduracidin isolated from cultures of Streptomyces fungicidicus. It has a very strong activity against Gram-positive bacteria, and is not easy to produce drug-resistant. It can promote the livestock, poultry growth, and could improve the feed conversion ratio. Another, it can be used for the following 4-month-old pig feed: the dosage is 2.5 (10 × 104U) -20 (80 × 104U) g / t; and it also be used for the following 10-week-old chickens feed usage is 1-10g / t, but at egg-laying period, it is disabled.
You can still convert the following datas into molecular structure:
(1)InChI:InChI=1S/C107H138Cl2N26O31.H2O/c1-7-51(2)17-12-10-8-9-11-13-19-76(144)120-74(47-77(145)146)92(152)126-80-55(6)166-102(162)86(60-28-38-68(143)39-29-60)132-88(148)52(3)117-90(150)73(46-63-49-116-104(112)119-63)124-106(164)134-100(160)84(61-43-69(108)87(147)70(109)44-61)128-93(153)75(50-136)123-97(157)81(56-20-30-64(139)31-21-56)127-91(151)72(45-62-48-115-103(111)118-62)122-89(149)71(18-16-41-114-105(113)163)121-94(154)78(53(4)137)125-98(158)82(57-22-32-65(140)33-23-57)130-99(159)83(58-24-34-66(141)35-25-58)129-95(155)79(54(5)138)133-107(165)135(42-15-14-40-110)101(161)85(131-96(80)156)59-26-36-67(142)37-27-59;/h9,11,13,19-39,43-44,51-55,62-63,71-75,78-86,136-143,147H,7-8,10,12,14-18,40-42,45-50,110H2,1-6H3,(H,117,150)(H,120,144)(H,121,154)(H,122,149)(H,123,157)(H,125,158)(H,126,152)(H,127,151)(H,128,153)(H,129,155)(H,130,159)(H,131,156)(H,132,148)(H,133,165)(H,145,146)(H3,111,115,118)(H3,112,116,119)(H3,113,114,163)(H2,124,134,160,164);1H2/b11-9+,19-13+; ;
(2)InChIKey:InChIKey=NJCUSQKMYNTYOW-MWUYRYRWSA-N;
(3)Smiles:N1(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(=O)NC(C(=O)NC(C(=O)NC(C(=O)OC(C(C(=O)NC(C1=O)c1ccc(cc1)O)NC(=O)C(CC(=O)O)NC(=O)/C=C\C=C\CCCCC(CC)C)C)c1ccc(cc1)O)C)CC1N=C(NC1)N)c1cc(c(c(c1)Cl)O)Cl)CO)c1ccc(cc1)O)CC1N=C(NC1)N)CCCNC(=O)N)C(O)C)c1ccc(cc1)O)c1ccc(cc1)O)C(O)C)CCCCN.O.
The toxicity data of Enduracidin as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 100mg/kg (100mg/kg) | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. | |
| mouse | LD50 | intramuscular | > 5gm/kg (5000mg/kg) | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. | |
| mouse | LD50 | intraperitoneal | 750mg/kg (750mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. |
| mouse | LD50 | intravenous | 30mg/kg (30mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. |
| mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. | |
| mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. | |
| rabbit | LD50 | intravenous | 92mg/kg (92mg/kg) | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. | |
| rat | LD50 | intramuscular | > 5gm/kg (5000mg/kg) | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. | |
| rat | LD50 | intraperitoneal | 830mg/kg (830mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. |
| rat | LD50 | intravenous | 66600ug/kg (66.6mg/kg) | BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. |
| rat | LD50 | oral | > 10gm/kg (10000mg/kg) | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. | |
| rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969. |
