10040-98-9Relevant articles and documents
Luminescent sensing of Fe3+ and K+ by three novel imidazole dicarboxylate-based MOFs
Huang, Qiuying,Wang, Jifeng,Wang, Qi,Li, Gang
, p. 193 - 204 (2017)
In this paper, three luminescent metal–organic frameworks, namely: [Zn(p-IPhHIDC)]n (1), {[Cd(p-IPhIDC)(H2O)]·CH3OH}n (2) and [Zn(p-TIPhHIDC)]n (3), bearing two novel substituted imidazole dicarboxyla
Cofacial porphyrin dimers assembled from N-heterocyclic carbene-metal bonds
Rose, Clémence,Lebrun, Aurélien,Clément, Sébastien,Richeter, Sébastien
, p. 9603 - 9606 (2018)
A porphyrin bearing four imidazolium rings on the meso positions was used as an N-heterocyclic carbene (NHC) precursor for the synthesis of porphyrin dimers with face-to-face orientations. The porphyrins are connected through the formation of eight M-CNHC bonds, with M = AgI or AuI.
Magnetically retrievable lepidocrocite supported copper oxide nanocatalyst (Fe-CuO) for N-arylation of imidazole
Sivakami,Babu, S. Ganesh,Dhanuskodi,Karvembu
, p. 8571 - 8578 (2015)
A simple and efficient lepidocrocite-supported copper oxide catalyst (Fe-CuO) has been successfully prepared by a simple precipitation method in aqueous medium from readily available inexpensive starting materials and was used as a heterogeneous nanocatal
A convenient and efficient method for the synthesis of new 2-(4-amino substituted benzilidine) indanone derivatives
Teimuri-Mofrad, Reza,Nikbakht, Roghaye,Gholamhosseini-Nazari, Mahdi
, p. 7501 - 7511 (2016)
An efficient and improved process for the synthesis of novel 1-indanones derivatives has been developed. In the first step of the presented new process, 4-bromobenzaldehyde reacts with 5, 6-dimethoxy-2, 3-dihydro-1H-inden-1-one by N-arylation of correspon
Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX
Allam, Heba Abdelrasheed,Fahim, Samar H.,F.Abo-Ashour, Mahmoud,Nocentini, Alessio,Elbakry, Mohamed E.,Abdelrahman, Mohamed A.,Eldehna, Wagdy M.,Ibrahim, Hany S.,Supuran, Claudiu T.
, p. 547 - 556 (2019)
Herein we report the design and synthesis of three different sets of novel benzenesulfonamides (5a-e, 7a-e and 10a-d) incorporating hydrophilic/hydrophobic tails by hydrazido or hydrazino linkers. The newly synthesized benzenesulfonamides were examined in vitro for their inhibitory activity towards four human (h) carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, hCA I, II, IX and XII using a stopped-flow CO2 hydrase assay. All these isoforms were inhibited by the sulfonamides (5a-e, 7a-e and 10a-d) with variable degrees in the following KI ranges: 76.8–357.4 nM for hCA I, 8.2–94.6 nM for hCA II, 2.0–46.3 nM for hCA XI, and 8.3–88.3 nM for hCA XII. The sulfonamide 7d exhibited potent anti-proliferative activity against breast MCF-7 cancer cell line under both normoxic and hypoxic conditions with IC50 values equal 3.32 ± 0.06 and 8.53 ± 0.32 μM, respectively, which are comparable to the reference drug doxorubicin (IC50 = 2.36 ± 0.04 and 8.39 ± 0.25 μM, respectively). Furthermore, 7d was screened for cell cycle disturbance and apoptosis induction in MCF-7 cells. It was found to persuade cell cycle arrest at G2-M stage as well as to alter the Sub-G1 phase, also, 7d resulted in a significant increase in the percent of annexinV-FITC positive apoptotic cells from 1.03 to 18.54%. Molecular docking study was carried out for 7d within the hCA IX and hCA XII active sites to rationalize the obtained inhibition results.
Study of SNAr reactions of halobenzenes with imidazole under ultrasonic and microwave irradiation
Meciarova, Maria,Podlesna, Janka,Toma, Stefan
, p. 419 - 423 (2004)
Nucleophilic aromatic substitution reactions with imidazole of haloarenes having strongly electron-withdrawing groups were studied under ultrasonic and microwave irradiations. The course of the SNAr reactions was found to be strongly dependent on the electron-withdrawing properties of the substituents as well as on the leaving ability of the halogen atom. Microwave irradiation allowed to shorten the reaction time and to increase the yields compared with ultrasonic irradiation. Springer-Verlag 2004.
Biocatalytic Cross-Coupling of Aryl Halides with a Genetically Engineered Photosensitizer Artificial Dehalogenase
Fu, Yu,Huang, Jian,Wu, Yuzhou,Liu, Xiaohong,Zhong, Fangrui,Wang, Jiangyun
, p. 617 - 622 (2021)
Devising artificial photoenzymes for abiological bond-forming reactions is of high synthetic value but also a tremendous challenge. Disclosed herein is the first photobiocatalytic cross-coupling of aryl halides enabled by a designer artificial dehalogenase, which features a genetically encoded benzophenone chromophore and site-specifically modified synthetic NiII(bpy) cofactor with tunable proximity to streamline the dual catalysis. Transient absorption studies suggest the likelihood of energy transfer activation in the elementary organometallic event. This design strategy is viable to significantly expand the catalytic repertoire of artificial photoenzymes for useful organic transformations.
A highly selective colorimetric chemosensor for detecting the respective amounts of iron(II) and iron(III) ions in water
Liang, Zuo-Qin,Wang, Cai-Xia,Yang, Jia-Xiang,Gao, Hong-Wen,Tian, Yu-Peng,Tao, Xu-Tang,Jiang, Min-Hua
, p. 906 - 910 (2007)
A novel colorimetric chemosensor containing terpyridine was synthesized. It showed high selectivity and sensitivity for Fe(ii) and Fe(iii) ions in neutral aqueous solution in the presence of other metal ions such as Cd2+, Cr3+, Znsu
N-arylation of heterocycles with activated chloro- and fluoroarenes using nanocrystalline copper(II) oxide
Kantam, M. Lakshmi,Yadav, Jagjit,Laha, Soumi,Sreedhar, Bojja,Jha, Shailendra
, p. 1938 - 1942 (2007)
Nanocrystalline copper oxide was found to be an effective heterogeneous catalyst for the N-arylation of heterocycles with activated chloro- and fluoroarenes using potassium carbonate as base. N-Arylated products were isolated in good to excellent yields. The catalyst can be used for five cycles with almost consistent activity.
Attaching azoles to Hantzsch 1,4-dihydropyridines: Synthesis, theoretical investigation of nonlinear optical properties, antimicrobial evaluation and molecular docking studies
Dengiz, Cagatay,Gündüz, Miyase G?zde,Ko?ak Aslan, Ebru,Nikodinovic-Runic, Jasmina,Skaro Bogojevic, Sanja
, (2022)
In the present study, we designed three novel compounds via the combination of two precious nitrogen-containing scaffolds; 1,4-dihydropyridine (DHP) and azole, in the same molecule. To synthesize the title compounds, initially, azolyl benzaldehydes were o
