1123738-15-7Relevant articles and documents
Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N-Hydroxysuccinimidyl Formate as CO Surrogate
Barré, Ana?s,T?nta?, Mihaela-Liliana,Alix, Florent,Gembus, Vincent,Papamica?l, Cyril,Levacher, Vincent
, p. 6537 - 6544 (2015)
An efficient Pd-catalyzed carbonylation protocol is described for the coupling of a large panel of aryl, heteroaryl, benzyl, vinyl and allyl halides 2 with the unusual N-hydroxysuccinimidyl (NHS) formate 1 as a CO surrogate to afford the corresponding valuable NHS esters 3. High conversion to the coupling products was achieved with up to 98% yield by means of Pd(OAc)2/Xantphos catalyst system.
Synthesis and c-met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: Identification of 3-(4-acetylpiperazin-1-yl)-5- (3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent
Wang, Yuanxiang,Ai, Jing,Wang, Ying,Chen, Yi,Wang, Lu,Liu, Gang,Geng, Meiyu,Zhang, Ao
scheme or table, p. 2127 - 2142 (2011/06/17)
By use of an improved synthetic strategy, a series of 3,5-disubstituted and 3,5,7-trisubstituted quinolines were readily prepared. 3,5,7-Trisubstituted quinolines 21a-c, 21l, and 27a-c were identified as the most potent c-Met inhibitors with IC50/su
Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase
Porter, John,Lumb, Simon,Lecomte, Fabien,Reuberson, James,Foley, Anne,Calmiano, Mark,le Riche, Kelly,Edwards, Helen,Delgado, Jean,Franklin, Richard J.,Gascon-Simorte, Jose M.,Maloney, Alison,Meier, Christoph,Batchelor, Mark
, p. 397 - 400 (2011/03/17)
A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of the
