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CAS

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143655-58-7

8-Acetylamino-6-fluoro-5-methyl-1-tetralone is a chemical compound with a molecular formula C13H11NO2F. It is a fluoro-substituted tetralone derivative with an acetylamino group attached to the 8-position and a methyl group attached to the 5-position.

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  • N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide

    Cas No: 143655-58-7

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  • 143655-58-7 Structure

  • Basic information

    1. Product Name: 8-Acetylamino-6-fluoro-5-methyl-1-tetralone
    2. Synonyms:
    3. CAS NO:143655-58-7
    4. Molecular Formula:
    5. Molecular Weight: 235.258
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 143655-58-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 8-Acetylamino-6-fluoro-5-methyl-1-tetralone(CAS DataBase Reference)
    10. NIST Chemistry Reference: 8-Acetylamino-6-fluoro-5-methyl-1-tetralone(143655-58-7)
    11. EPA Substance Registry System: 8-Acetylamino-6-fluoro-5-methyl-1-tetralone(143655-58-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 143655-58-7(Hazardous Substances Data)

143655-58-7 Usage

Uses

Used in Pharmaceutical Industry:
8-Acetylamino-6-fluoro-5-methyl-1-tetralone is used as a synthetic intermediate for the production of pharmaceuticals. Its structural features make it a valuable building block for the synthesis of biologically active compounds, contributing to the development of new drugs.
Used in Agrochemical Industry:
8-Acetylamino-6-fluoro-5-methyl-1-tetralone is also used as a synthetic intermediate in the production of agrochemicals, playing a role in the development of effective and innovative products for agricultural applications.
Used as a Research Tool:
8-Acetylamino-6-fluoro-5-methyl-1-tetralone may be used as a research tool in chemical and pharmaceutical laboratories. Its unique structure allows researchers to explore its potential applications and properties, furthering the understanding of its role in various chemical reactions and processes.

Check Digit Verification of cas no

The CAS Registry Mumber 143655-58-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,6,5 and 5 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 143655-58:
(8*1)+(7*4)+(6*3)+(5*6)+(4*5)+(3*5)+(2*5)+(1*8)=137
137 % 10 = 7
So 143655-58-7 is a valid CAS Registry Number.

143655-58-7Downstream Products

143655-58-7Relevant articles and documents

Intermediate for synthesizing camptothecin derivative as well as preparation method and application thereof

-

, (2020/08/09)

The invention relates to the technical field of organic compound synthesis, in particular to an intermediate for synthesizing a camptothecin derivative as well as a preparation method and applicationof the intermediate. An intermediate A can be obtained by acylation, bromination and cross coupling reaction of 3-fluoro-4-methylaniline. The intermediate A can be used for preparing an intermediate Bso as to further prepare Exatecan mesylate. The intermediate compound B can be obtained by rearrangement reaction of the intermediate A; Exatecan mesylate can be obtained by subjecting the intermediate compound B to alpha-site acetamido and amino deprotection, condensation reaction and hydrolysis reaction. The method has the advantages of low price of reaction initiators, mild reaction conditionsof each step, simplicity and convenience in operation, high yield and suitability for industrial production.

Aminotetralone derivatives and preparation process thereof

-

, (2008/06/13)

The present invention pertains to a process for the preparation of Compound (4) through the below-described reaction route: STR1 wherein R1 and R2 each represents H, halogen, OH or C1-6 alkyl group; X and Y each represents a protected amino group and n stands for 0 to 4. According to the above process, an aminotetralone derivative which is an intermediate useful for an industrial preparation of a camptothecin derivative can be obtained in a convenient manner and in a high yield.

Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues

Sugimori, Masamichi,Ejima, Akio,Ohsuki, Satoru,Uoto, Kouichi,Mitsui, Ikuo,Kawato, Yasuyoshi,Hirota, Yasuhide,Sato, Keiki,Terasawa, Hirofumi

, p. 2308 - 2318 (2007/10/03)

Nineteen ring A- and F-modified hexacyclic analogues of camptothecin were synthesized by Friedlander condensation of appropriately substituted bicyclic amino ketones with tricyclic ketone and were evaluated for cytotoxicity and topoisomerase I inhibitory

Hexa-cyclic compound

-

, (2008/06/13)

A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: STR1 The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.

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