1437051-59-6Relevant articles and documents
Palladium-Catalyzed Suzuki Coupling and NIS-Mediated Dehydrogenative Cylcoetherification: A Concise Approach to 6,6-Disubstituted 6H-benzo[c]chromenes and Total Synthesis of Didehydroconicol
Satyanarayana, Gedu,Shekhar, Chander
, (2022/03/08)
Benzo[c]chromones are valuable tricyclic systems of natural and biological significance. Herein, we report a concise approach of 6,6-disubstituted 6H-benzo[c]chromenes in a two-step sequence starting from ortho-bromo benzylic alcohols and arylboronic acids, using intermolecular palladium-catalyzed C?C and intramolecular N-Iodosuccinimide (NIS) mediated key C?O bonds construction. Besides, the current method explored broad substrate scope under robust conditions. Notably, the practicality of the present approach is further extended for the total synthesis of Didehydroconicol.
Rh-Catalyzed Asymmetric Hydrogenation of α,β- and β,β-Disubstituted Unsaturated Boronate Esters
Hou, Guohua,Shen, Xin,Yan, Qiaozhi,Zi, Guofu
, (2020/05/08)
A highly enantioselective hydrogenation of α,β-unsaturated boronate esters catalyzed by Rh-(S)-DTBM-Segphos complex has been developed. Both (Z)-α,β- and β,β-disubstituted substrates can be successfully hydrogenated to afford chiral boronates with excellent enantioselectivities, up to 98 % ee. Furthermore, the obtained chiral boronate esters, as important versatile synthetic intermediates are successfully transformed to the corresponding chiral alcohols, amines and other important derivatives with maintained enantioselectivities.
BORON-CONTAINING SMALL MOLECULES
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Paragraph 0405, (2013/06/04)
This invention provides novel compounds, methods of using the compounds, and pharmaceutical compositions containing the compounds.
