155793-46-7 Usage
Uses
Used in Pharmaceutical Industry:
4-(trifluoromethyl)quinolin-3-amine is used as a building block for the synthesis of various pharmaceutical compounds due to its unique structure and functional groups. The trifluoromethyl group can enhance the lipophilicity and metabolic stability of the resulting drugs, while the amine group can be further modified to improve pharmacokinetic properties and target specific biological receptors.
Used in Agrochemical Industry:
4-(trifluoromethyl)quinolin-3-amine is used as a precursor in the development of agrochemicals, such as insecticides, herbicides, and fungicides. The presence of the trifluoromethyl group can increase the bioactivity and selectivity of the final products, making them more effective in controlling pests and diseases in agriculture.
Used in Organic Synthesis:
4-(trifluoromethyl)quinolin-3-amine is used as a versatile intermediate in organic synthesis for the preparation of various quinoline-based compounds. The amine functional group allows for further reactions, such as acylation, alkylation, and arylation, enabling the synthesis of a wide range of quinoline derivatives with diverse applications in materials science, dyes, and other fields.
Check Digit Verification of cas no
The CAS Registry Mumber 155793-46-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,7,9 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 155793-46:
(8*1)+(7*5)+(6*5)+(5*7)+(4*9)+(3*3)+(2*4)+(1*6)=167
167 % 10 = 7
So 155793-46-7 is a valid CAS Registry Number.
155793-46-7Relevant articles and documents
AN ACTIVATED TRIFLUOROMETHYL GROUP AS A SYNTHON FOR 2-SUBSTITUTED BENZOTHIAZOLE AND BENZOXAZOLE
Kiselyov, Alexander S.,Hojjat, Maryam,Aken, Koen Van,Strekowski, Lucjan
, p. 775 - 782 (2007/10/02)
Dianions derived from 2-mercaptoaniline and 2-hydroxyaniline are cyclized to 2-substituted benzothiazole and benzoxazole, respectively, in the reaction with ortho or para trifluoromethyl-substituted anilines and quinolinamines that involves the CF3 group.
Experimental and Computational Studies of Trifluoromethylation of Aromatic Amines by the System Trifluoroiodomethane-Zinc-Sulfur Dioxide
Strekowski, Lucjan,Hojjat, Maryam,Petterson, Steven E.,Kiselyov, Alexander S.
, p. 1413 - 1416 (2007/10/02)
Several trifluoromethyl-substituted aromatic and heteroaromatic amines have been obtained by the reactions of the corresponding amines with the title reagent system.Computational results provide rationalization for the observed regioselectivities and support a mechanism in which the electrophilic trifluoromethyl radicals interact with the aromatic ring at the sites with the greatest electron density of the HOMO orbitals, and then the resultant adducts are oxidized to cations.The products obtained are potential building blocks for a number of heterocyclic systems.