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1614246-24-0

5-chloro-N3-ethylpyridazine-3,4-diamine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1614246-24-0 Structure

  • Basic information

    1. Product Name: 5-chloro-N3-ethylpyridazine-3,4-diamine
    2. Synonyms:
    3. CAS NO:1614246-24-0
    4. Molecular Formula:
    5. Molecular Weight: 172.617
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1614246-24-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-chloro-N3-ethylpyridazine-3,4-diamine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-chloro-N3-ethylpyridazine-3,4-diamine(1614246-24-0)
    11. EPA Substance Registry System: 5-chloro-N3-ethylpyridazine-3,4-diamine(1614246-24-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1614246-24-0(Hazardous Substances Data)

1614246-24-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1614246-24-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,4,2,4 and 6 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1614246-24:
(9*1)+(8*6)+(7*1)+(6*4)+(5*2)+(4*4)+(3*6)+(2*2)+(1*4)=140
140 % 10 = 0
So 1614246-24-0 is a valid CAS Registry Number.

1614246-24-0Relevant articles and documents

Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865)

Owen, Robert M.,Blakemore, David,Cao, Lishuang,Flanagan, Neil,Fish, Rebecca,Gibson, Karl R.,Gurrell, Rachel,Huh, Chan Woo,Kammonen, Juha,Mortimer-Cassen, Elisabeth,Nickolls, Sarah A.,Omoto, Kiyoyuki,Owen, Dafydd,Pike, Andy,Pryde, David C.,Reynolds, David S.,Roeloffs, Rosemarie,Rose, Colin,Stead, Clara,Takeuchi, Mifune,Warmus, Joseph S.,Watson, Christine

supporting information, p. 5773 - 5796 (2019/05/15)

The design, optimization, and evaluation of a series of novel imidazopyridazine-based subtype-selective positive allosteric modulators (PAMs) for the GABAA ligand-gated ion channel are described. From a set of initial hits multiple subseries were designed and evaluated based on binding affinity and functional activity. As designing in the desired level of functional selectivity proved difficult, a probability-based assessment was performed to focus the project's efforts on a single subseries that had the greatest odds of delivering the target profile. These efforts ultimately led to the identification of two precandidates from this subseries, which were advanced to preclinical safety studies and subsequently to the identification of the clinical candidate PF-06372865.

IMIDAZOPYRIDAZINE DERIVATIVES AS MODULATORS OF THE GABAA RECEPTOR ACTIVITY.

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Page/Page column 65, (2016/01/01)

The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R and R6 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.

Chemical Compounds

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Paragraph 0463; 0464, (2014/06/25)

The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.

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