53180-76-0

Basic information

• Product Name: 3,5-dichloropyridazin-4-amine
• Synonyms: 3,5-dichloropyridazin-4-amine;4-Amino-3,5-dichloropyridazine;4-PyridazinaMine, 3,5-dichloro-
• CAS NO: 53180-76-0
• Molecular Formula: C₄H₃Cl₂N₃
• Molecular Weight: 163.995
• Mol File: 53180-76-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 176-178 °C
• Boiling Point: 331.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.606±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.03±0.10(Predicted)
• CAS DataBase Reference: 3,5-dichloropyridazin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dichloropyridazin-4-amine(53180-76-0)
• EPA Substance Registry System: 3,5-dichloropyridazin-4-amine(53180-76-0)

Safety Data

• Hazardous Substances Data: 53180-76-0(Hazardous Substances Data)

Usage

Uses

3,5-dichloropyridazin-4-amine?is a heterocyclic derivative, which can be used as a pharmaceutical intermediate and used in pharmaceutical experimental research.

Upstream product

• 14161-11-6 3,4,5-trichloropyridazine 
• 7664-41-7 ammonia 

Downstream Products

• 20744-39-2 4-aminopyridazine 
• 1614246-24-0 5-chloro-N³-ethylpyridazine-3,4-diamine 
• 1187205-78-2 5-chloro-3-(2-fluoro-4-trifluoromethylphenyl)pyridazin-4-ylamine 
• 591-55-9 pyrimidin-5-amine 
• 173279-42-0 4-amino-5-chloro-3-<1-(2-fluorobenzyl)hydrazino>pyridazine 

Relevant articles and documents

IMIDAZOPYRIDAZINE DERIVATIVES AS MODULATORS OF THE GABAA RECEPTOR ACTIVITY.

The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R and R6 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.

Chemical Compounds

The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.

Synthesis and anticonvulsant activity of 3H-imidazo[4,5-c]-pyridazine, 1H-imidazo[4,5-d]pyridazine and 1H-benzimidazole analogues of 9-(2-fluorobenzyl)-6-methylamino-9H-purine

The 3H-imidazo[4,5-c]pyridazine, 1H-imidazo[4,5-d]pyridazine, and 1H-benzimidazole analogues of the potent anticonvulsant purine 9-(2-fluorobenzyl)-6-methylamino-9H-purine (1, 78U79) were synthesized and tested for anticonvulsant activity. The 3H-imidazo[4,5-c]pyridazines 8 and 9 were prepared in five stages from 3,4,5-trichloropyridazine (2). The 1H-imidazolo[4,5-d]pyridazine 15 was synthesized in four stages from 5-[(benzyloxy)methyl]-1,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one (10a). The benzimidazole analogues 18 and 20 were prepared from 2,6-dinitroaniline in three stages. These compounds were one-tenth or less as active as 1 in protecting rats against maximal electroshock-induced seizures.