220243-81-2 Usage
Uses
Used in Organic Synthesis:
TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-HYDROXYHEXANOATE is used as a building block for the synthesis of various organic compounds due to its unique structure and reactivity, contributing to the development of new products in the chemical industry.
Used in Pharmaceutical Research:
In the pharmaceutical industry, TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-HYDROXYHEXANOATE is utilized as a key component in the research and development of new medications, leveraging its properties to enhance drug efficacy and safety.
Used in Drug Delivery Systems:
TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-HYDROXYHEXANOATE is employed as a component in drug delivery systems to improve the bioavailability and targeted delivery of therapeutic agents, enhancing their effectiveness and reducing side effects.
Used as a Protective Group in Peptide Synthesis:
In peptide synthesis, TERT-BUTYL 2-(TERT-BUTOXYCARBONYLAMINO)-6-HYDROXYHEXANOATE serves as a protective group to shield functional groups during the synthesis process, ensuring the correct formation of peptide bonds and facilitating the production of desired peptide sequences.
Check Digit Verification of cas no
The CAS Registry Mumber 220243-81-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,2,4 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 220243-81:
(8*2)+(7*2)+(6*0)+(5*2)+(4*4)+(3*3)+(2*8)+(1*1)=82
82 % 10 = 2
So 220243-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H29NO5/c1-14(2,3)20-12(18)11(9-7-8-10-17)16-13(19)21-15(4,5)6/h11,17H,7-10H2,1-6H3,(H,16,19)
220243-81-2Relevant articles and documents
Collagen cross-links: Synthesis of pyridinoline, deoxypyridinoline and their analogues
Adamczyk, Maciej,Johnson, Donald D.,Reddy, Rajarathnam E.
, p. 63 - 88 (2007/10/03)
An efficient chiral synthesis of (S,S)-(-)-3g, a key intermediate for the preparation of collagen cross-links pyridinoline (Pyd, 1) and deoxypyridinoline (Dpd, 2) was achieved from (4S)-5(tert-butoxy)-4-[(tert- butoxycarbonyl)amino]-5-oxopentanoic acid (21b). Quaternization of (S,S)-(- )-3g with iodide (2S, 5R)-(+)-4a followed by hydrolysiS provided a first chiral synthesis of natural (+)-Pyd (1). 1-(2S)-(+)-Pyd (1) was also synthesized from (S,S)-(-)-3g and iodide (2S, 5S)-(+)-4a. Similarly, quaternization of (S,S)-(-)-3g with iodide (2S)-(-)-4b, which was prepared from (2S)-(-)-6-amino-2[(tert-butoxycarbonyl)amino]hexanoic acid (31) in three steps, followed by hydrolysis afforded natural (+)-Dpd (2) in 5.3% overall yield. Also, the synthesis of racemic Dpd [(±)-2] and a variety of its analogues is presented.
