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57987-77-6

7,8-dichloro-1,2,3,4-tetrahydroisoquinolinium chloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 57987-77-6 Structure

  • Basic information

    1. Product Name: 7,8-dichloro-1,2,3,4-tetrahydroisoquinolinium chloride
    2. Synonyms: 7,8-dichloro-1,2,3,4-tetrahydroisoquinolinium chloride;7,8-dichloro-1,2,3,4-tetrahydroisoquinoline;SKF-64139;7,8-dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride
    3. CAS NO:57987-77-6
    4. Molecular Formula: C9H9Cl2N*ClH
    5. Molecular Weight: 238.5414
    6. EINECS: 261-064-5
    7. Product Categories: N/A
    8. Mol File: 57987-77-6.mol

  • Chemical Properties

    1. Melting Point: 225-227 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
    2. Boiling Point: 310.7°Cat760mmHg
    3. Flash Point: 141.7°C
    4. Appearance: /
    5. Density: g/cm3
    6. Vapor Pressure: 0.000589mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 7,8-dichloro-1,2,3,4-tetrahydroisoquinolinium chloride(CAS DataBase Reference)
    11. NIST Chemistry Reference: 7,8-dichloro-1,2,3,4-tetrahydroisoquinolinium chloride(57987-77-6)
    12. EPA Substance Registry System: 7,8-dichloro-1,2,3,4-tetrahydroisoquinolinium chloride(57987-77-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 57987-77-6(Hazardous Substances Data)

57987-77-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 57987-77-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,9,8 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 57987-77:
(7*5)+(6*7)+(5*9)+(4*8)+(3*7)+(2*7)+(1*7)=196
196 % 10 = 6
So 57987-77-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H9Cl2N.ClH/c10-8-2-1-6-3-4-12-5-7(6)9(8)11;/h1-2,12H,3-5H2;1H

57987-77-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 7,8-dichloro-1,2,3,4-tetrahydroisoquinolinium chloride

1.2 Other means of identification

Product number -
Other names 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:57987-77-6 SDS

57987-77-6Downstream Products

57987-77-6Relevant articles and documents

Method for preparing tetrahydroisoquinolines

-

, (2008/06/13)

A method for preparing 1,2,3,4-tetrahydroisoquinolines comprising heating N-halo or hydroxyethyl-N-benzylamines in an aluminum chloride melt at 160°-210°.

Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline

-

, (2008/06/13)

A novel process for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline by cyclizing N-acetyl-2,3-dichlorobenzylaminoacetaldehyde dimethyl acetal with a Lewis acid, reducing, and hydrolyzing the resulting acylated isoquinoline is disclosed.

Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis: I. Chloro-substituted 1,2,3,4-tetrahydroisoquinolines

Bondinell,Chapin,Girard,Kaiser,Krog,Pavloff,Schwartz,Silvestri,Vaidya,Lam,Wellman,Pendleton

, p. 506 - 511 (2007/10/02)

In a search for inhibitors of epinephrine biosynthesis as potential therapeutic agents, a series of 13 ring-chlorinated 1,2,3,4-tetrahydroisoquinolines was prepared. These compounds were tested initially for their ability to inhibit rabbit adrenal phenylethanolamine N-methyltransferase (PNMT) in vitro. Enzyme-inhibitor dissociation constants, determined for the six most potent members of the series, indicated the following order of decreasing potency: 7,8-Cl2>6,7,8-Cl3>7-Cl~8-Cl>5,6,7,8-Cl4>5,7,8-Cl3. These compounds were subsequently examined for PNMT-inhibiting activity in intact rats and mice. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SK&F 64139) was the most potent member of the series both in vitro and in vivo and is currently undergoing clinical investigation.

INTRAMOLECULAR FRIEDEL-CRAFTS ALKYLATIONS. II. AN EFFICIENT SYNTHESIS OF BIOLOGICALLY ACTIVE 1,2,3,4-TETRAHYDROISOQUINOLINES

Mendelson, W. L.,Spainhour, C. B.,Jones, S. S.,Lam, B. L.,Wert, K. L.

, p. 1393 - 1396 (2007/10/02)

A new synthesis of tetrahydroisoquinolines bearing electron withdrawing groups is presented.The scope and mechanism of the reaction are discussed.Many of these tetrahydroisoquinolines are potent inhibitors of the enzyme PNMT.

7 AND 8-Halo substituted 1,2,3,4-tetrahydroisoquinoline compounds

-

, (2008/06/13)

1,2,3,4-Tetrahydroisoquinoline compounds having 7 and 8 halo substituents are inhibitors of phenylethanolamine N-methyltransferase.

Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase

-

, (2008/06/13)

Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.

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