99446-53-4 Usage
Uses
Used in Medicinal Chemistry:
5-Methoxy-pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester is used as a building block for the synthesis of pharmaceuticals and biologically active molecules. Its versatile chemical structure allows for the creation of new compounds with potential therapeutic effects.
Used in Research and Development:
In the pharmaceutical industry, 5-Methoxy-pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester is utilized as a research chemical, aiding in the development of new drugs. Its properties make it a promising candidate for further exploration and experimentation in drug discovery processes.
Used as a Precursor in Organic Synthesis:
5-Methoxy-pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester also serves as a precursor in organic synthesis, enabling the formation of more complex molecules that can be applied in various chemical and pharmaceutical applications.
Overall, the compound's multifaceted applications underscore its importance in the advancement of pharmaceutical sciences and the ongoing pursuit of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 99446-53-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,4,4 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 99446-53:
(7*9)+(6*9)+(5*4)+(4*4)+(3*6)+(2*5)+(1*3)=184
184 % 10 = 4
So 99446-53-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2O3/c1-3-16-11(14)9-7-12-13-5-4-8(15-2)6-10(9)13/h4-7H,3H2,1-2H3
99446-53-4Relevant articles and documents
Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors
Kendall, Jackie D.,O'Connor, Patrick D.,Marshall, Andrew J.,Frédérick, Rapha?l,Marshall, Elaine S.,Lill, Claire L.,Lee, Woo-Jeong,Kolekar, Sharada,Chao, Mindy,Malik, Alisha,Yu, Shuqiao,Chaussade, Claire,Buchanan, Christina,Rewcastle, Gordon W.,Baguley, Bruce C.,Flanagan, Jack U.,Jamieson, Stephen M.F.,Denny, William A.,Shepherd, Peter R.
experimental part, p. 69 - 85 (2012/03/08)
We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class Ia PI3 kinases. We investigated the SAR around the pyrazolo[1,5-a]pyridine ring system, and found compound 5x to be a particularly potent example (p110α IC50 0.9 nM). This compound inhibits cell proliferation and phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity, and showed in vivo activity in an HCT-116 human xenograft model.
PYRAZOLO[1,5-A]PYRIDINES AND THEIR USE IN CANCER THERAPY
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Page/Page column 63-64, (2009/03/07)
Pyrazolo[1,5-a]pyridines are described, including methods for their preparation, and their use as agents or drugs for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
