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| Name |
Thyroxine |
EINECS | N/A |
| CAS No. | 7488-70-2 | Density | 2.4440 (estimate) |
| PSA | 92.78000 | LogP | 5.25760 |
| Solubility | N/A | Melting Point |
235-236oC |
| Formula | C15H11I4NO4 | Boiling Point | N/A |
| Molecular Weight | 0 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
N/A |
Thyroxine Chemical Properties
Molecular Structure:
IUPAC Name: 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
Molecular Weight: 776.87002 g/mol
Molecular Formula: C15H11I4NO4
Index of Refraction: 1.795
Molar Refractivity: 125.44 cm3
Molar Volume: 294.7 cm3
Polarizability: 49.73×10-24cm3
Surface Tension: 79.6 dyne/cm
Density: 2.635 g/cm3
Flash Point: 302.3 °C
Enthalpy of Vaporization: 90.78 kJ/mol
Boiling Point: 576.3 °C at 760 mmHg
XLogP3-AA: 2.4
H-Bond Donor: 3
H-Bond Acceptor: 5
Rotatable Bond Count: 5
Tautomer Count: 2
Exact Mass: 776.68668
MonoIsotopic Mass: 776.68668
Topological Polar Surface Area: 92.8
Heavy Atom Count: 24
Complexity: 420
InChI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)
InChIKey: XUIIKFGFIJCVMT-UHFFFAOYSA-N
Thyroxine Uses
The Thyronines (CAS NO.7488-70-2) act on nearly every cell in the body. They act to increase the basal metabolic rate, affect protein synthesis, help regulate long bone growth (synergy with growth hormone), neuronal maturation and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness.
Thyroxine Production
Thyroxine (CAS NO.7488-70-2) is synthesized via the iodination of tyrosines(monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin.
Thyroxine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | oral | 485ug/kg (0.485mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION | European Journal of Pediatrics. Vol. 150, Pg. 217, 1991. |
| man | TDLo | oral | 30ug/kg/3W-I (0.03mg/kg) | CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE | British Medical Journal. Vol. 292, Pg. 1185, 1986. |
| women | TDLo | oral | 42ug/kg/1W-I (0.042mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Neurology. Vol. 35, Pg. 1792, 1985. |
Thyroxine Safety Profile
Human toxic effects at low oral doses. Human systemic effects by ingestion: EKG changes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of I− and NOx.
Thyroxine Specification
Thyroxine (CAS NO.7488-70-2) is also known as 2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propanoic acid , 2-Amino-3-[4-(4-hydroxy-3,5-diiodphenoxy)-3,5-diiodphenyl]propansäure , 2-ammonio-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate , 3-(4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)alanine , 3,5,3',5'-Tetraiodothyronine .
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