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Name	2-(2,7-Dichloro-9H-fluoren-4-yl)oxirane	EINECS	922-480-9
CAS No.	53221-14-0	Density	1.449±0.06 g/cm3(Predicted)
PSA	12.53000	LogP	4.63590
Solubility	N/A	Melting Point	N/A
Formula	C₁₅H₁₀Cl₂O	Boiling Point	442.0±45.0 °C(Predicted)
Molecular Weight	277.15	Flash Point	N/A
Transport Information	N/A	Appearance	white crystal powder
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	2-(2,7-Dichloro-9H-fluoren-4-yl)-Oxirane	Article Data	4

2-(2,7-Dichloro-9H-fluoren-4-yl)oxirane Synthetic route

: 2-chloro-1-(2, 7-dichloro-9H-fluoren-4-yl) ethanol

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

Conditions

Conditions	Yield
With sodium methylate at 50 - 60℃;
With sodium hydroxide In methanol Reflux;
With sodium ethanolate In ethanol Large scale;	235 kg

: 7012-16-0
2,7-dichloro-9H-fluorene

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aluminum (III) chloride / dichloromethane / -5 - 0 °C 2: sodium tetrahydroborate / ethanol / 1 h / -5 - 5 °C 3: sodium methylate / 50 - 60 °C View Scheme
Multi-step reaction with 3 steps 1: aluminum (III) chloride / dichloromethane / 0 - 5 °C 2: sodium tetrahydroborate / methanol / 0 - 20 °C 3: sodium hydroxide / methanol / Reflux View Scheme
Multi-step reaction with 3 steps 1: aluminum (III) chloride / dichloromethane / 8 h / 0 - 5 °C / Large scale 2: sodium tetrahydroborate / ethanol / 3 h / -5 - 5 °C / Large scale 3: sodium ethanolate / ethanol / Large scale View Scheme

: 2-chloro-1-(2,7-dichloro-9H-fluoren-4-yl)-ethan-1-one

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / ethanol / 1 h / -5 - 5 °C 2: sodium methylate / 50 - 60 °C View Scheme
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / methanol / 0 - 20 °C 2: sodium hydroxide / methanol / Reflux View Scheme
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / ethanol / 3 h / -5 - 5 °C / Large scale 2: sodium ethanolate / ethanol / Large scale View Scheme

: 86-73-7
9H-fluorene

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: chlorine / acetic acid / 15 h / 35 - 45 °C 2: aluminum (III) chloride / dichloromethane / -5 - 0 °C 3: sodium tetrahydroborate / ethanol / 1 h / -5 - 5 °C 4: sodium methylate / 50 - 60 °C View Scheme
Multi-step reaction with 4 steps 1: chlorine; acetic acid / 40 - 42 °C 2: aluminum (III) chloride / dichloromethane / 0 - 5 °C 3: sodium tetrahydroborate / methanol / 0 - 20 °C 4: sodium hydroxide / methanol / Reflux View Scheme
Multi-step reaction with 4 steps 1: hydrogenchloride; chlorine; acetic acid / 10 h / 90 °C / Inert atmosphere; Large scale 2: aluminum (III) chloride / dichloromethane / 8 h / 0 - 5 °C / Large scale 3: sodium tetrahydroborate / ethanol / 3 h / -5 - 5 °C / Large scale 4: sodium ethanolate / ethanol / Large scale View Scheme

: 75-77-4
chloro-trimethyl-silane

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: (2-chloro-2-(2,7-dichloro-9H-fluoren-4-yl)ethoxy)trimethylsilane

Conditions

Conditions	Yield
With zinc(II) oxide In dichloromethane at 20℃; for 2h;	73%

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 7101-31-7
dimethyl diselenide

: 1-(2,7-dichloro-9H-fluoren-4-yl)-2-(methylselanyl)ethan-1-ol

Conditions

Conditions	Yield
In methanol at 5 - 10℃; Inert atmosphere;	73%

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 111-92-2
dibutylamine

: 69759-61-1
2-dibutylamino-1-(2,7-dichloro-9H-fluoren-4-yl)ethanol

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: 53221-25-3
2,7-dichloro-4-[2-(dibutyl amino)-1-hydroxyethyl]-9H-fluoren-9-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol / 15 h / 78 °C 2: sodium hydroxide; oxygen / ethanol / 6 h / 23 - 70 °C View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

A: 2-dibutylamino-1-{2,7-dichloro-9-[1-(4-chlorophenyl)meth-(E)-ylidene]-9H-fluoren-4-yl}ethanol

B: lumefantrine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol / 15 h / 78 °C 2: sodium hydroxide / ethanol / 6 h / 23 - 70 °C View Scheme

: 53221-14-0
2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

: (RS,Z)-2-dibutylamino-2-[2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: zinc(II) oxide / dichloromethane / 2 h / 20 °C 2: potassium carbonate / acetonitrile / 16 h / Inert atmosphere; Reflux 3: hydrogenchloride / tetrahydrofuran; water / 50 °C / Inert atmosphere 4: sodium hydroxide / ethanol / 1 h / Inert atmosphere; Reflux; Green chemistry View Scheme

2-(2,7-Dichloro-9H-fluoren-4-yl)oxirane Chemical Properties

Product Name: 2-(2,7-Dichloro-9H-fluoren-4-yl)oxirane
Molecular Structure of 2-(2,7-Dichloro-9H-fluoren-4-yl)oxirane (CAS NO.53221-14-0):

Molecular Formula: C₁₅H₁₀Cl₂O
Molecular Weight: 277.15
CAS NO: 53221-14-0

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