The 2-Naphthalenesulfonyl Chloride is an organic compound with the formula C10H7ClO2S. The IUPAC name of this chemical is naphthalene-2-sulfonyl chloride. With the CAS registry number 93-11-8 and EINECS 202-219-9, it is also named as Naphthalene-2-sulfonic acid chloride. The product's categories are Organic Building Blocks; Sulfonyl Halides; Sulfur Compounds. It is light yellow to beige powder which is insoluble in water and sensitive to moisture. In addition, this chemical should be sealed in the container and stored in the dry place.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 3.22; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.22; (4)ACD/LogD (pH 7.4): 3.22; (5)ACD/BCF (pH 5.5): 164.3; (6)ACD/BCF (pH 7.4): 164.3; (7)ACD/KOC (pH 5.5): 1341.39; (8)ACD/KOC (pH 7.4): 1341.39; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 42.52 Å2; (13)Index of Refraction: 1.643; (14)Molar Refractivity: 57.95 cm3; (15)Molar Volume: 160.2 cm3; (16)Polarizability: 22.97×10-24 cm3; (17)Surface Tension: 50.5 dyne/cm; (18)Density: 1.414 g/cm3; (19)Flash Point: 178.4 °C; (20)Enthalpy of Vaporization: 59.4 kJ/mol; (21)Boiling Point: 371.3 °C at 760 mmHg; (22)Vapour Pressure: 2.23E-05 mmHg at 25°C.
Preparation of 2-Naphthalenesulfonyl Chloride: It can be obtained by naphthalene-2-sulfonic acid ; sodium-salt. This reaction needs reagent POCl3, catalytic agent N,N-Dimethylacetamide and solvents acetonitrile, tetrahydrothiophene 1,1-dioxide at temperature of 68-72 °C. The reaction time is 15 min. The yield is 91%.
Uses of 2-Naphthalenesulfonyl Chloride: It is used in the determination of amines and used in organic synthesis. For example: it can react with aniline to get naphthalene-2-sulfonanilide. This reaction needs reagent Et3N and solvent CH2Cl2 at temperature of 20 °C. The yield is 95%.
When you are using this chemical, please be cautious about it as the following:
It can cause burns. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
People can use the following data to convert to the molecule structure.
1. SMILES:ClS(=O)(=O)c2ccc1c(cccc1)c2
2. InChI:InChI=1/C10H7ClO2S/c11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H
3. InChIKey:OPECTNGATDYLSS-UHFFFAOYAP