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Cas Database |
| Name |
4-Benzyl-2-hydroxymorpholin-3-one |
EINECS | 811-794-0 |
| CAS No. | 287930-73-8 | Density | 1.292 g/cm3 |
| PSA | 49.77000 | LogP | 0.30170 |
| Solubility | N/A | Melting Point |
134.0 to 138.0 °C |
| Formula | C11H13NO3 | Boiling Point | 441.718 °C at 760 mmHg |
| Molecular Weight | 207.229 | Flash Point | 220.943 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
4-benzyl-2-hydroxy-morpholin-3-one; |
Article Data | 5 |
4-Benzyl-2-hydroxymorpholin-3-one Synthetic route
| Conditions | Yield |
|---|---|
| In tetrahydrofuran Reflux; | 91% |
| In tetrahydrofuran Reflux; | 91% |
| In tetrahydrofuran; water for 21h; Heating; | 76% |
| In tetrahydrofuran; water at 60 - 65℃; for 8h; Inert atmosphere; | 27.5 g |
- 110843-90-8
4-benzyl-morpholine-2,3-dione
- 287930-73-8
4-benzyl-2-hydroxy-morpholin-3-one
| Conditions | Yield |
|---|---|
| With L-Selectride | 88% |
| With sodium hydroxide; dihydrogen peroxide; L-Selectride In tetrahydrofuran; water at 10℃; for 1h; | 80% |
- 104-63-2
N-Benzylethanolamine
- 563-96-2
2,2-dihydroxyacetic acid
- 287930-73-8
4-benzyl-2-hydroxy-morpholin-3-one
| Conditions | Yield |
|---|---|
| In tetrahydrofuran; water at 65℃; for 18h; | 75% |
- 109745-70-2, 19757-97-2
methyl glyoxylate methyl hemi-acetal
- 104-63-2
N-Benzylethanolamine
- 287930-73-8
4-benzyl-2-hydroxy-morpholin-3-one
| Conditions | Yield |
|---|---|
| 15% |
- 108228-02-0
Methoxy-(1-methoxy-1-methyl-ethoxy)-acetic acid methyl ester
- 104-63-2
N-Benzylethanolamine
- 287930-73-8
4-benzyl-2-hydroxy-morpholin-3-one
| Conditions | Yield |
|---|---|
| Stage #1: Methoxy-(1-methoxy-1-methyl-ethoxy)-acetic acid methyl ester; N-Benzylethanolamine With sodium hydride In tetrahydrofuran Stage #2: With hydrogenchloride Further stages.; |
- 104-63-2
N-Benzylethanolamine
- 287930-73-8
4-benzyl-2-hydroxy-morpholin-3-one
| Conditions | Yield |
|---|---|
| Stage #1: N-Benzylethanolamine; (1-ethoxy-ethoxy)-methoxy-acetic acid methyl ester With sodium hydride In tetrahydrofuran Stage #2: With hydrogenchloride Further stages.; |
- 104-63-2
N-Benzylethanolamine
- 287930-73-8
4-benzyl-2-hydroxy-morpholin-3-one
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 88 percent / Li(sec-Bu)3BH View Scheme | |
| Multi-step reaction with 2 steps 1: 68 percent / ethanol; hexane / 20 °C 2: 80 percent / lithium tri(sec-butyl)borohydride; sodium hydroxide; hydrogen peroxide / tetrahydrofuran; H2O / 1 h / 10 °C View Scheme |
- 368-63-8, 68120-60-5, 127852-28-2
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
- 287930-73-8
4-benzyl-2-hydroxy-morpholin-3-one
- 287930-75-0
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
| Conditions | Yield |
|---|---|
| Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5 - 30℃; for 1h; Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile for 3h; Further stages; | 96% |
| Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5 - 30℃; for 1h; Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile for 2h; Stage #3: With tetrahydrolinalool; potassium tert-butylate In hexane at -10 - -5℃; for 14h; Solvent; | 96% |
| Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5℃; for 1h; Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile at 25℃; for 4h; Temperature; Reagent/catalyst; |
- 545-06-2
trichloroacetonitrile
- 287930-73-8
4-benzyl-2-hydroxy-morpholin-3-one
- 502536-97-2
2,2,2-trichloro-acetimidic acid 4-benzyl-3-oxo-morpholin-2-yl ester
| Conditions | Yield |
|---|---|
| With 1,8-diazabicyclo[5.4.0]undec-7-ene In n-heptane; toluene at 20℃; for 18h; | 91% |
- 407-25-0
trifluoroacetic anhydride
- 287930-73-8
4-benzyl-2-hydroxy-morpholin-3-one
- 502537-07-7
trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester
| Conditions | Yield |
|---|---|
| In acetonitrile at 5 - 34℃; |
4-Benzyl-2-hydroxymorpholin-3-one Specification
The 3-Morpholinone,2-hydroxy-4-(phenylmethyl)-, with the CAS registry number 287930-73-8, is also known as 2-Hydroxy-4-benzylmorpholin-3-one. It belongs to the product category of Pharmacetical. This chemical's molecular formula is C11H13NO3 and molecular weight is 207.2258. Its systematic name is called 4-benzyl-2-hydroxymorpholin-3-one.
Physical properties of 3-Morpholinone,2-hydroxy-4-(phenylmethyl)-: (1)ACD/LogP: 0.30 ; (2)#H bond acceptors: 4; (3)#H bond donors: 1; (4)#Freely Rotating Bonds: 3; (5)Index of Refraction: 1.595; (6)Molar Refractivity: 54.506 cm3; (7)Molar Volume: 160.346 cm3; (8)Surface Tension: 57.361 dyne/cm; (9)Density: 1.292 g/cm3; (10)Flash Point: 220.943 °C; (11)Enthalpy of Vaporization: 73.678 kJ/mol; (12)Boiling Point: 441.718 °C at 760 mmHg; (13)Vapour Pressure: 0 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C2N(Cc1ccccc1)CCOC2O
(2)InChI: InChI=1/C11H13NO3/c13-10-11(14)15-7-6-12(10)8-9-4-2-1-3-5-9/h1-5,11,14H,6-8H2
(3)InChIKey: CAGSEMPCDRYWFN-UHFFFAOYAC
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