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4-Fluorobenzyl chloride

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Name

4-Fluorobenzyl chloride

EINECS 206-516-4
CAS No. 352-11-4 Density 1.191 g/cm3
PSA 0.00000 LogP 2.56450
Solubility 417mg/L(temperature not stated) Melting Point -18 °C
Formula C7H6ClF Boiling Point 181.6 °C at 760 mmHg
Molecular Weight 144.576 Flash Point 64 °C
Transport Information UN 2920 8/PG 2 Appearance clear colorless to slightly yellow liquid
Safety 26-36/37/39-45 Risk Codes 22-34
Molecular Structure Molecular Structure of 352-11-4 (alpha-Chloro-p-fluorotoluene) Hazard Symbols CorrosiveC
Synonyms

Toluene,a-chloro-p-fluoro- (6CI,7CI,8CI);1-(Chloromethyl)-4-fluorobenzene;4-Fluorophenylmethyl chloride;NSC 25084;p-Fluorobenzyl chloride;a-Chloro-4-fluorotoluene;a-Chloro-p-fluorotoluene;

Article Data 31

4-Fluorobenzyl chloride Specification

The 4-Fluorobenzyl chloride with cas registry number of 352-11-4 is also known as alpha-Chloro-p-fluorotoluene. Both its systematic name and IUPAC name are the same which is called 1-(chloromethyl)-4-fluorobenzene. This chemical is clear colorless to slightly yellow liquid which is sensitive to lachrymatory. Its EINECS registry number is 206-516-4.

The physical properties about this chemical are: (1)ACD/LogP: 2.54; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.54; (4)ACD/LogD (pH 7.4): 2.54; (5)ACD/BCF (pH 5.5): 50.04; (6)ACD/BCF (pH 7.4): 50.04; (7)ACD/KOC (pH 5.5): 572.8; (8)ACD/KOC (pH 7.4): 572.8; (9)#H bond acceptors: 0; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1 ; (12)Index of Refraction: 1.505; (13)Molar Refractivity: 36.01 cm3; (14)Molar Volume: 121.3 cm3; (15)Surface Tension: 32.4 dyne/cm; (16)Density: 1.191 g/cm3; (17)Flash Point: 64 °C; (18)Enthalpy of Vaporization: 40.07 kJ/mol; (19)Boiling Point: 181.6 °C at 760 mmHg; (20)Vapour Pressure: 1.15 mmHg at 25°C ; (21)Refractive index: 1.512-1.514.

Preparation of 4-Fluorobenzyl chloride: it can be made by 4-fluoro-benzyl alcohol with reagent HCl. This reaction is Chlorination which occurs at temperature of 70 ℃. The reaction time is about 3.5 hours. And the yield is 72.7%.

Uses of 4-Fluorobenzyl chloride: it can react with piperidine to give N-(4-Fluorbenzyl)-piperidin by using solvent toluene. The yield is 92%.

When you are using this chemical, please be cautious about it as the following:
This chemcial is harmful if swallowed. And it can cause burns. Therefore, wear suitable protective clothing, gloves and eye/face protection during using it. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you feel unwell, seek medical advice immediately (show the label whenever possible).

You can still convert the following datas into molecular structure:
(1)SMILES: ClCc1ccc(F)cc1;
(2)InChI: InChI=1/C7H6ClF/c8-5-6-1-3-7(9)4-2-6/h1-4H,5H2;
(3)InChIKey: IZXWCDITFDNEBY-UHFFFAOYAJ

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