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Cas Database |
| Name |
6-Chlorouracil |
EINECS | 224-258-0 |
| CAS No. | 4270-27-3 | Density | 1.61 g/cm3 |
| PSA | 65.72000 | LogP | -0.28340 |
| Solubility | 4.885g/L(25 oC) | Melting Point |
290-295 °C |
| Formula | C4H3ClN2O2 | Boiling Point | 300 °C |
| Molecular Weight | 146.533 | Flash Point | 182°C |
| Transport Information | N/A | Appearance | White powder |
| Safety | 26-36 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
6-chloro-1H-pyrimidine-2,4-dione;4-Chlorouracil; |
Article Data | 34 |
6-Chlorouracil Synthetic route
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water for 3.5h; Reflux; | 98% |
| With sodium hydroxide In water for 2h; Reflux; | 98% |
| Stage #1: 2,4,6-trichloropyrimidine With sodium hydroxide In water for 1h; Reflux; Stage #2: With hydrogenchloride In water pH=2 - 3; | 97% |
| Conditions | Yield |
|---|---|
| With sodium hydroxide Reflux; Schlenk technique; Inert atmosphere; | 92% |
| Conditions | Yield |
|---|---|
| 43% | |
| With hydrogen bromide | |
| With hydrogenchloride |
| Conditions | Yield |
|---|---|
| With trichlorophosphate In acetonitrile at 120℃; for 0.166667h; Microwave irradiation; |
| Conditions | Yield |
|---|---|
| In butan-1-ol for 8h; Heating; | 100% |
- 4270-27-3
6-chlorouracil
- 108-42-9
3-chloro-aniline
- 7269-03-6
6-(3-chlorophenylamino)pyrimidine-2,4(1H,3H)-dione
| Conditions | Yield |
|---|---|
| at 170℃; for 0.333333h; | 99% |
| for 2h; Reflux; | 95% |
| In melt at 180 - 200℃; |
| Conditions | Yield |
|---|---|
| With lithium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; | 98.8% |
| Stage #1: 6-chlorouracil With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 0.166667h; Stage #2: chloromethyl methyl ether at 0℃; for 0.333333h; | 90% |
| Conditions | Yield |
|---|---|
| In chlorobenzene for 8h; Reflux; | 98% |
| In chlorobenzene for 7h; Substitution; Heating; | 59% |
- 4270-27-3
6-chlorouracil
- 930-69-8
sodium thiophenolate
- 15422-05-6
6-(phenylthio)pyrimidine-2,4(1H,3H)-dione
| Conditions | Yield |
|---|---|
| In N,N,N,N,N,N-hexamethylphosphoric triamide at 90℃; for 0.05h; microwave irradiation; | 98% |
| Conditions | Yield |
|---|---|
| at 150℃; for 1h; Inert atmosphere; | 98% |
| at 160℃; for 0.333333h; microwave irradiation; | 95% |
| at 180℃; for 0.5h; | 91% |
6-Chlorouracil Chemical Properties
Molecular Formula: C4H3ClN2O2
Molecular Weight: 146.53
EINECS: 224-258-0
Polar Surface Area: 40.62 Å2
Index of Refraction: 1.587
Molar Refractivity: 30.56 cm3
Molar Volume: 90.9 cm3
Surface Tension: 57.3 dyne/cm
Density: 1.61 g/cm3
Index of Refraction: 1.587
Melting Point: 290-295°C
IUPAC Name: 6-Chloro-1H-pyrimidine-2,4-dione
Appearance of 6-Chlorouracil (CAS NO.4720-27-3): A white crystalline powder
Product Categories: Pyridines, Pyrimidines, Purines and Pteredines ; Biochemistry ; Nucleobases and their analogs ; Nucleosides, Nucleotides & Related Reagents
Synonyms of 6-Chlorouracil (CAS NO.4720-27-3): 6-Chloro-2,4-(1H,3H)-pyrimidinedione ; 4-Chloro-2,6-dihydroxypyrimidine
Following is the molecular structure of 6-Chlorouracil (CAS NO.4720-27-3):
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6-Chlorouracil Safety Profile
Safety Information of 6-Chlorouracil (CAS NO.4720-27-3):
Hazard Codes: Xi 
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Irritant
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