Reference

Inhibitors of Bacillus subtilis DNA polymerase III

Inhibitors of Bacillus subtilis DNA polymerase III. 64054-67-7 which is the cas registry number of one of substances is just one of reagents here. 6-(Arylalkylamino)uracils and 6-anilinouracils. Brown, Neal C.; Gambino, Joseph; Wright, George E. (Dep. Pharmacol., Univ. Massachusetts Sch. Med., Worcester, Mass., USA). J. Med. Chem., 20(9), 1186-9 (English) 1977. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 7, 28 Sixteen title compds. were prepd. by the reaction of 6-chlorouracil [4270-27-3] with the appropriate amines in refluxing glyme as solvent, or by the reaction of 3-methyl-6-aminouracil [21236-97-5] with an amine. The most potent inhibitor of Bacillus subtilis DNA polymerase III [37217-33-7] was I [64054-69-9]. Structure-activity relations including those with wild-type and mutant enzymes indicate that the enzyme inhibitor binding site is compact, the phenyl ring adopts a specific active conformation, and part of the enzyme site interacts with phenyl ring substituents. .

Electronic absorption spectra and acidity of new uracil fused systems - derivatives of 1,3-dithiolo[4,5-d]pyrimidine

Electronic absorption spectra and acidity of new uracil fused systems - derivatives of 1,3-dithiolo[4,5-d]pyrimidine. Neiland, O.; Zagorskaya, N. N. (Rizh. Tekh. Univ., Riga 226048, Latvia). Khim. Geterotsikl. Soedin., (3), 416-21 (Russian) 1992. CODEN: KGSSAQ.Several substances like 4270-27-3 may be metioned in this study. ISSN: 0132-6244. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) UV absorption data for neutral and mono- and dianionic forms of the title fused uracils I (Z = N+Et2 ClO4-, O, S, Se) were used for detn. of first and second pK values. The regiochem. of ionization was discussed on the basis of electronic spectra. Acidity increased in the series Z = O, S, Se, as well as stability with respect to alk. 4270-27-3 is just another one chemical used in this study. hydrolysis. ..