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Boc-L-Valine
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Name

Boc-L-Valine

 EINECS 237-307-6
CAS No. 13734-41-3 Density 1.079 g/cm3
PSA 75.63000 LogP 2.01120
Solubility insoluble Melting Point 77-80 °C(lit.)
Formula C10H19NO4 Boiling Point 341.8 °C at 760 mmHg
Molecular Weight 217.265 Flash Point 160.5 °C
Transport Information N/A Appearance white fine crystalline powder
Safety 24/25-36-26 Risk Codes 20/21/22-36/37/38
Molecular Structure Molecular Structure of 13734-41-3 ((S)-2-(Boc-amino)-3-methylbutyric acid) Hazard Symbols HarmfulXn
Synonyms

N-BOC-valine;N-a-tert-Butoxycarbonyl-L-valine;NSC 197197;tert-Butoxycarbonyl-L-valine;Boc-Val-OH;Valine,N-carboxy-, N-tert-butyl ester, L- (6CI,8CI);(S)-2-(tert-Butoxycarbonylamino)-3-methylbutanoic acid;(S)-N-tert-Butoxycarbonylvaline;BOC-valine;

Article Data 160

Boc-L-Valine Synthetic route

72-18-4

L-valine

24424-99-5

di-tert-butyl dicarbonate

13734-41-3

t-Boc-L-valine

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water100%
With sodium hydroxide In 1,4-dioxane; water at 0℃;100%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 16h;100%
95499-91-5

Boc-Val-NHNHPh

13734-41-3

t-Boc-L-valine

Conditions
ConditionsYield
With oxygen In acetonitrile for 16h; tyrosinase, phosphate buffer pH 7;99%
With phosphate buffer; oxygen; tyrosinase In water; acetonitrile at 20℃; for 16h; pH=7.0;99%
128359-98-8

Boc-Val-O-t-Bu

13734-41-3

t-Boc-L-valine

Conditions
ConditionsYield
With cerium(III) chloride; sodium iodide In acetonitrile for 6h; Heating;99%
With water; iodine In acetonitrile for 5h; Heating;89%
72-18-4

L-valine

104272-92-6

2-t-butoxycarbonyloxy-3,6-diisopropylpyrazine

13734-41-3

t-Boc-L-valine

Conditions
ConditionsYield
With triethylamine In water; acetonitrile for 24h; Ambient temperature;98%

(S)-(1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate

A

13734-41-3

t-Boc-L-valine

B

1033736-87-6

C16H10O3S

Conditions
ConditionsYield
In chloroform-d1 for 0.233333h; Photolysis; Inert atmosphere;A 97%
B n/a
72-18-4

L-valine

89985-91-1

tert-butyl pyridin-2-yl carbonate

A

142-08-5

2-hydroxypyridin

B

13734-41-3

t-Boc-L-valine

Conditions
ConditionsYield
With triethylamine In water; N,N-dimethyl-formamide for 9h; Ambient temperature;A n/a
B 92%
72-18-4

L-valine

1538-75-6

2,2-dimethylpropanoic anhydride

13734-41-3

t-Boc-L-valine

Conditions
ConditionsYield
Stage #1: L-valine With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃;
Stage #2: 2,2-dimethylpropanoic anhydride In tetrahydrofuran; water at 0 - 20℃; for 12h;		90%
66447-55-0

((S)-1-benzylcarbamoyl-2-methyl-propyl)-carbamic acid tert-butyl ester

13734-41-3

t-Boc-L-valine

Conditions
ConditionsYield
With formic acid; potassium hydroxide In ethanol at 70℃; for 1h;89%
With hydrogen; palladium on activated charcoal
58561-04-9

N-tert-butoxycarbonyl-L-valine methyl ester

13734-41-3

t-Boc-L-valine

Conditions
ConditionsYield
With lithium hydroxide In methanol for 8h;85%
With water; lithium hydroxide In methanol for 4h;
72-18-4

L-valine

75844-68-7

tert-butyl 2-oxo-1,3-oxazole-3(2H)-carboxylate

13734-41-3

t-Boc-L-valine

Conditions
ConditionsYield
With dmap; triethylamine In 1,4-dioxane; water for 15h; Ambient temperature;84%

Boc-L-Valine Chemical Properties

Synonyms: BOC-VALINE;BOC-VALINE-OH;BOC-VAL-OH;BOC-VAL;BOC-L-VAL;BOC-L-VALINE;BOC-L-VAL-OH
Molecular formula: C10H19NO4
Molar weight: 217.26
Molecular Structure: 
Product Categories: Boc-Amino Acids and Derivative;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series;Pharmaceutical intermediate
mp : 77-80 ℃(lit.)
alpha : -6.3 o (c=1,CH3COOH)
refractive index : -6.5 ° (C=1, AcOH)
storage temp.:  -20℃

 

Boc-L-Valine Uses

Uses in the multi-peptide synthesis, serves as the amino acid protection monomer. Patterned SILK past Lu Wei intermediate .

Boc-L-Valine Safety Profile

Hazard Codes  :Xn
The Risk Statements information of  Boc-L-Valine:
20/21/22:  Harmful by inhalation, in contact with skin and if swallowed 
36/37/38:  Irritating to eyes, respiratory system and skin 
The Safety Statements information of  Boc-L-Valine:
26:  In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice 
36:  Wear suitable protective clothing 
24/25:  Avoid contact with skin and eyes 
WGK Germany : 3
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