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Detail of "13734-41-3"

  • CAS Number:
  • 13734-41-3
  • Name:
  • L-Valine,N-[(1,1-dimethylethoxy)carbonyl]-

  • Superlist Name:
  • Boc-L-Valine
  • Molecular Structure:
  • Formula:
  • C10H19NO4
  • Molecular Weight:
  • 232.24
  • Deleted CAS:
  • 91602-34-5|253591-28-5
  • Synonyms:
  • N-BOC-valine;N-a-tert-Butoxycarbonyl-L-valine;NSC 197197;tert-Butoxycarbonyl-L-valine;Boc-Val-OH;Valine,N-carboxy-, N-tert-butyl ester, L- (6CI,8CI);(S)-2-(tert-Butoxycarbonylamino)-3-methylbutanoic acid;(S)-N-tert-Butoxycarbonylvaline;BOC-valine;
  • EINECS:
  • 237-307-6
  • Density:
  • 1.079 g/cm3
  • Melting Point:
  • 77-80 °C(lit.)
  • Boiling Point:
  • 341.8 °C at 760 mmHg
  • Flash Point:
  • 160.5 °C
  • Appearance:
  • white fine crystalline powder
  • Hazard Symbols:
  • HarmfulXn
  • Risk Codes:
  • 20/21/22-36/37/38
  • Safety:
  • 24/25-36-26 Details
  • particular:
  • particular

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Assay:99%  Appearance:Off-white to...  Package:in 25kgs car...Storage:normal condi...  Transportation:non dangerou...  Application:intermediate...

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CAS No.13734-41-3 Boc-L-Valine

Category : Intermediates/Pharmaceutical intermediates CAS NO : 13734-41-3 EC NO : 237-307-6 MF : C10H18NO4 MW : 216.2548 Synonyms : Boc-l-Val-OH;N-Boc-L-Valine;Boc-L-Valine;(Boc-L-Val-OH, N-Boc-L-Valine);Boc-L-Val-OH, N-Boc-L-Valine;Boc-Val-OH ;N-(tert-butoxycarbonyl)-L-

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CAS No.13734-41-3 Boc-L-Valine

Category : Intermediates/Pharmaceutical intermediates CAS NO : 13734-41-3 EC NO : 237-307-6 MF : C10H18NO4 MW : 216.2548 Synonyms : Boc-l-Val-OH;N-Boc-L-Valine;Boc-L-Valine;(Boc-L-Val-OH, N-Boc-L-Valine);Boc-L-Val-OH, N-Boc-L-Valine;Boc-Val-OH ;N-(tert-butoxycarbonyl)-L-

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Assay:98.0%  Appearance:white to off...

Name: Boc-L-Valine; Synonyms: N-(tert-Butoxycarbonyl)-L-valine; N-[(1,1-Dimethylethoxy)carbonyl]-L-valine; (S)-2-(Boc-amino)-3-methylbutyric acid; Identification: Molecular Formula: C10H19NO4; Molecular Weight: 217.26; EINECS: 237-3

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Reference

Allyl esters as selectively removable carboxy-protecting functions in peptide and N-glycopeptide syntheses
Allyl esters as selectively removable carboxy-protecting functions in peptide and N-glycopeptide syntheses. Waldmann, Herbert; Kunz, Horst (Inst. Org. Chem., Univ. Mainz, Mainz D-6500, Fed. Rep. Ger.). Liebigs Ann. Chem., (10), 1712-25 (German) 1983. CODEN: LACHDL. ISSN: 0170-2041. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 33 Allyl esters can be used for the protection of carboxyl groups in peptide and glycopeptide synthesis. Allyl esters are stable under acidic conditions used for the removal of Me3CO2C (Boc) and PhCH2O2C groups, but allyl esters are cleaved smoothly by treatment with catalytic amts. of (PPh3)3RhCl in EtOH-H2O (9:1) under neutral or weakly basic conditions leaving the N-protecting function and the N-glycosidic bond untouched.There are some commonly used reagents with their cas registry numbers 13734-41-3 and 88224-29-7 in this article. Amino acids were esterified with allyl alc. in benzene contg. p-MeC6H4SO3H to give amino acid allyl ester tosylates. N-Glycosidic asparagine I (R = allyl) was deblocked by (PPh3)3RhCl to give I (R = H), which was coupled with dipeptide allyl esters to give glycotripeptides II (X-X1 = Leu-Phe, Ile-Leu, Thr-Ser). .
Studies on trypsin inhibitors
Studies on trypsin inhibitors. Part VII. Synthesis of protected peptides related to sequence 1-14 and 36-52 of porcine pancreatic secretory trypsin inhibitor II (Kazal). Tomatis, Roberto; Guggi, Augusto; Salvadori, Severo; Rocchi, Raniero (Ist. Chim. Farm. Tossicol., Univ. Ferrara, Ferrara, Italy). Int. J. Pept. Protein Res., 9(2), 137-47 (English) 1977. CODEN: IJPPC3. DOCUMENT TYPE: Journal CA Section: 34 (Synthesis of Amino Acids, Peptides, and Proteins) Section cross-reference(s): 7 BOC-Glu(OCMe3)-Asn-Lys(Tfa)-Lys(Tfa)-Arg-Gln(Mbh)-Thr-Pro-Val-Le u-Ile-Gln-Lys(Tfa)-Ser-Gly-Pro-Cys(Acm)-OH [I; BOC = Me3CO2C, Tfa = CF3CO, Mbh = [4-(MeO)C6H4]2CH, Acm = AcNHCH2], the protected 36-52 sequence of the title trypsin inhibitor, was prepd. by coupling BOC-Glu(OCMe3)-Asn-Lys(Tfa)-Lys(Tfa)-Arg-Gln(Mbh)-Thr-Pro-OH (II) to H-Val-Leu-Ile-Gln-Lys(Tfa)-Ser-Gly-Pro-Cys(Acm)-OH by the mixed anhyd. 62577-21-3 and 13734-41-3 which are cas registry numbers of chemicals are mentioned. method. I was also prepd. by coupling BOC-Glu(OCMe3)-Asn-Lys(Tfa)-Lys(Tfa)-Arg-Gln(Mbh)-Thr-Pro-Val-Le u-Ile-NHNH2 (III) to H-Gln-Lys(Tfa)-Ser-Gly-Pro-Cys(Acm)-OH by the azide method. II was coupled to H-Val-Leu-Ile-NHNHZ (Z = PhCH2OC) by dicyclohexylcarbodiimide to give III. Z-Arg(NO2)-Glu-Ala-Thr-Cys(Acm)-Thr-Ser-Glu-Val-Ser-Gly-Cys(Acm)- Pro-Lys(Tfa)-R (R = OH, NHNHBOC), the protected 1-14 sequence of the title trypsin inhibitor, were also prepd. by peptide fragmentation couplings. .
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