- Emde Degradation
-
Emde Degradation
H. Emde, Ber. 42, 2590 (1909); Ann. 391, 88 (1912).
Modification of the Hofmann degradation, q.v., method for reductive cleavage of the carbon-nitrogen bond by treatment of an alcoholic or aqueous solution of a quaternary ammonium halide with sodium amalgam. Also used as a catalytic method with palladium and platinum catalysts. The method succeeds with ring compounds not degraded by the Hofmann procedure:
Reviews: A. Birch, Org. React. 7, 143 278 (1953); F. Möller, Houben-Weyl 11/1, 973 (1955); Z. Spialter, J. A. Pappalardo, Acyclic Aliphatic Tertiary Amines (Macmillan, New York, 1965) pp 79-81. Photodegradation: V. Partail, Helv. Chim. Acta 68, 1952 (1985). Synthetic applications: J. G. Cannon et al., J. Med. Chem. 18, 110 (1975); J. Lévy et al., Tetrahedron Asymmetry 8, 4127 (1997).
Prev: Emmert Reaction
Next: Elbs Reaction - 【Back】【Close 】【Print】【Add to favorite 】
-
Health and Chemical more >
-
Hot Products
- 71838-47-6 Direct Yellow 137
- 9001-33-6 Ficin
- 58933-55-4 heliox
- 7783-90-6 Silver chloride (AgCl)
- 1652-63-7 1-Propanaminium,3-[[(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)sulfonyl]amino]-N,N,N-trimethyl-,iodide (1:1)
- 96-49-1 Ethylene carbonate
- 25036-25-3 Poly(Bisphenol A-co-epichlorohydrin) glycidyl end-capped
- 13183-79-4 5-Mercapto-1-methyltetrazole
- 182176-52-9 Ethaneperoxoic acid, reaction products with3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl thiocyanateand 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl thiocyanate
- 141856-57-7 5-benzyl-1-methyl-N-nitro-1,4,5,6-tetrahydro-1,3,5-triazin-2-amine
- 13455-36-2 COBALT PHOSPHATE HYDRATE
- 27848-84-6 Ergoline-8-methanol,10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8b)-