- Cytochalasin B
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Cas Database |
| Name |
Cytochalasin B |
EINECS | 239-000-2 |
| CAS No. | 14930-96-2 | Density | 1.209 g/cm3 |
| PSA | 95.86000 | LogP | 3.82090 |
| Solubility | ethanol: 20 mg/mL | Melting Point |
218-223 °C |
| Formula | C29H37NO5 | Boiling Point | 740.559 °C at 760 mmHg |
| Molecular Weight | 479.616 | Flash Point | 401.676 °C |
| Transport Information | UN 1544 6.1/PG 2 | Appearance | white to off-white powder |
| Safety | 28-36/37-45 | Risk Codes | 26/27/28-63-23/24/25 |
| Molecular Structure |
|
Hazard Symbols |
 T+,  T
|
| Synonyms |
24-Oxa[14]cytochalasa-6(12),13,21-triene-1,23-dione,7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-;2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione,16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(E,E)-(5R,9R,12aS,13S,15S,15aS,16S,18aS)- (8CI);2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione,6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-,[5R-(3E,5R*,9R*,11E,12aS*,13S*,15S*,15aS*,16S*,18aS*)]-;NSC107658;Phomin; |
Article Data | 3 |
Cytochalasin B Chemical Properties
Cytochalasin B (CAS No.:14930-96-2) is a cell-permeable mycotoxin. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments. It inhibits cell movement and induces nuclear extrusion. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Cytochalasin B inhibits glucose transport and platelet aggregation. It blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells. It is also used in cloning through nuclear transfer. Here enucleated recipient cells are treated with Hoechst stain containing cytochalsin B. Cytochalasin B makes the walls of the oocytes smoother and makes it easy for micro-manipulation so that the zona pellucida is not so rigid and can be easily pierced by the micro-needles.
Cytochalasin B Uses
Chemical Name: Cytochalasin B
CAS No.: 14930-96-2
EINECS: 239-000-2
RTECS: RO0205000
Molecular Formula: C29H37NO5
Molecular Weight: 479.61 g/mol
Melting Point: 218-223 °C
Density: 1.2 g/cm3
Flash Point: 401.7 °C
Boiling Point: 740.6 °C at 760 mmHg
Storage temp.: -20°C
Following is the structure of Cytochalasin B (CAS No.:14930-96-2):
Cytochalasin B Toxicity Data With Reference
| 1. | dni-hmn:oth 1 mg/L | CNREA8 Cancer Research. 45 (1985),311. | ||
| 2. | dni-hmn:hla 1 µmol/L | MUREAV Mutation Research. 92 (1982),427. | ||
| 3. | cyt-hmn:fbr 1 mg/L | JCLBA3 Journal of Cell Biology. 89 (1981),194. | ||
| 4. | cyt-hmn:oth 1 mg/L | JNCIAM Journal of the National Cancer Institute. 52 (1974),653. | ||
| 5. | cyt-mus:mmr 1 mg/L | ITCSAF In Vitro. 19 (1983),58. | ||
| 6. | ipr-ham TDLo:5 mg/kg (female 8D post):TER | TJADAB Teratology, A Journal of Abnormal Development. 22 (1980),59. | ||
| 7. | ipr-rat LD50:11 mg/kg | TOXIA6 Toxicon. 17 (1979),137. | ||
| 8. | ipr-mus LD50:30 mg/kg | FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. 38 (1979),438. |
Cytochalasin B Consensus Reports
EPA Genetic Toxicology Program.
Cytochalasin B Safety Profile
Poison by intraperitoneal route. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:
T+: Very toxic .gif){kind=small}
T: Toxic
Risk Statements about Cytochalasin B (CAS No.:14930-96-2):
R63 Possible risk of harm to the unborn child.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements about Cytochalasin B (CAS No.:14930-96-2):
S28 After contact with skin, wash immediately with plenty of soap-suds.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37: Wear suitable protective clothing and gloves.
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