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Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1)

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Name

Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1)

EINECS 246-930-2
CAS No. 25384-14-9 Density N/A
PSA 43.09000 LogP 2.85460
Solubility N/A Melting Point 285-289 °C(lit.)
Formula C8H10ClNO Boiling Point 251.8 °C at 760 mmHg
Molecular Weight 171.626 Flash Point 106.1 °C
Transport Information N/A Appearance N/A
Safety 26-36 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 25384-14-9 (2'-AMINOACETOPHENONE HYDROCHLORIDE) Hazard Symbols IrritantXi
Synonyms

Acetophenone,2'-amino-, hydrochloride (8CI);Ethanone, 1-(2-aminophenyl)-, hydrochloride(9CI);1-(2-Aminophenyl)ethanone hydrochloride;2'-Aminoacetophenonehydrochloride;o-Aminoacetophenone hydrochloride;

Article Data 4

Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1) Synthetic route

577-59-3

2-acetylnitrobenzene

25384-14-9

2-aminoacetophenone hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; tin(ll) chloride In ethanol; water at 30℃; Rate constant; Mechanism;
551-93-9

2-aminoacetophenone

25384-14-9

2-aminoacetophenone hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane; diethyl ether
25384-14-9

2-aminoacetophenone hydrochloride

4964-49-2

1-(2-aminophenyl)ethanone oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride In ethanol for 264h; Ambient temperature;94%
25415-67-2

ethyl isocaproate

25384-14-9

2-aminoacetophenone hydrochloride

342642-32-4

2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium acetate In water at 100℃; for 18h;93%
25384-14-9

2-aminoacetophenone hydrochloride

1078-19-9

6-methoxy-3,4-dihydro-1(2H)-naphthalenone

83876-53-3

3-methoxy-7-methyl-5,6-dihydrobenzacridine

Conditions
ConditionsYield
at 140℃; for 0.166667h;91%
108-94-1

cyclohexanone

25384-14-9

2-aminoacetophenone hydrochloride

6829-08-9

9-methyl-1,2,3,4-tetrahydroacridine

Conditions
ConditionsYield
at 110℃; Friedlaender condensation;89%
Stage #1: cyclohexanone; 2-aminoacetophenone hydrochloride at 90 - 110℃;
Stage #2: With hydrogenchloride In ethanol; water
Stage #3: With sodium hydroxide In ethanol; water pH=7;
89%
at 90 - 110℃;89%
at 90 - 110℃;89%
6836-19-7

7-Methoxy-1-tetralone

25384-14-9

2-aminoacetophenone hydrochloride

83876-52-2

2-methoxy-7-methyl-5,6-dihydrobenzacridine

Conditions
ConditionsYield
at 140℃; for 0.166667h;87%
33892-75-0

5-Methoxy-1-tetralone

25384-14-9

2-aminoacetophenone hydrochloride

83876-54-4

4-methoxy-7-methyl-5,6-dihydrobenzacridine

Conditions
ConditionsYield
at 140℃; for 0.166667h;84%
25384-14-9

2-aminoacetophenone hydrochloride

765-87-7

cyclohexane-1,2-dione

5298-71-5

6,7-dihydro-5,8-dimethyldibenzo<1,10>phenanthroline

Conditions
ConditionsYield
In various solvent(s) for 48h; Heating;79%
61362-78-5

8-bromo-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-one

25384-14-9

2-aminoacetophenone hydrochloride

1352285-82-5

1-bromo-2-methoxy-7-methyl-5,6-dihydrobenzo[c]acridine

Conditions
ConditionsYield
at 140℃; for 7h; Friedlaender synthesis; Neat (no solvent);35%

Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1) Specification

This chemical is called Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1), and its systematic name is 1-(2-aminophenyl)ethanone hydrochloride (1:1). With CAS registry number of 25384-14-9, its product categories are Aromatic Acetophenones & Derivatives (substituted); C7 to C8; Carbonyl Compounds; Ketones. Additionally, its classification code is TSCA Flag P [A commenced PMN (Premanufacture Notice) substance]. It should be stored in the cool and dry place.

Other characteristics of the Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1) can be summarised as followings: (1)ACD/LogP: 1.62; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.62; (4)ACD/LogD (pH 7.4): 1.62; (5)ACD/BCF (pH 5.5): 10.02; (6)ACD/BCF (pH 7.4): 10.03; (7)ACD/KOC (pH 5.5): 181.14; (8)ACD/KOC (pH 7.4): 181.25; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 20.31 Å2; (13)Flash Point: 106.1 °C; (14)Enthalpy of Vaporization: 48.91 kJ/mol; (15)Boiling Point: 251.8 °C at 760 mmHg; (16)Vapour Pressure: 0.0201 mmHg at 25°C.

Uses of this chemical: The Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1) could react with 2-methyl-cyclopent-2-enone, and obtain the 3,9-dimethyl-1H-cyclopenta[b]quinoline. This reaction needs the reagent of concd. hydrochloric acid, and the solvent of aq. ethanol. The yield is 21 %. In addition, this reaction should be taken for 19 hours with the heating.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure: 
1.SMILES: O=C(c1ccccc1N)C.Cl
2.InChI: InChI=1/C8H9NO.ClH/c1-6(10)7-4-2-3-5-8(7)9;/h2-5H,9H2,1H3;1H
3.InChIKey: APTPPYQXBFFQHZ-UHFFFAOYAJ

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