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Ethyl disulfide

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Name

Ethyl disulfide

EINECS 203-805-7
CAS No. 110-81-6 Density 0.99
PSA 50.60000 LogP 2.40760
Solubility Melting Point 95-98.5 °C(lit.)

Formula C4H10 S2 Boiling Point 152 - 154 C
Molecular Weight 122.255 Flash Point 40 ºC
Transport Information UN 1993 Appearance Clear to yellow liquid
Safety Moderately toxic by ingestion. A skin and eye irritant. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use foam or dry chemical. See also SULFIDES and SULFATES. Risk Codes R10;R36/37/38   
Molecular Structure Molecular Structure of 110-81-6 (Diethyl disulfide) Hazard Symbols
Synonyms

Ethyldisulfide (8CI); 3,4-Dithiahexane; Diethyl disulfide; Ethyl disulphide;Ethyldithioethane; NSC 8839

Article Data 257

Ethyl disulfide Synthetic route

74-96-4

ethyl bromide

110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With lithium sulfide; sulfur; cetyl trimethyl ammonium bromide In chloroform; water for 1h; Ambient temperature;94%
With water; oxygen; sodium carbonate; thiourea at 35 - 40℃; for 5h; Green chemistry;87%
With sodium carbonate; sulfur; thiourea In water at 40℃; for 3h; Green chemistry;84%
75-08-1

ethanethiol

110-81-6

Diethyl disulfide

Conditions
ConditionsYield
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In chloroform at 20℃;100%
With air; iron(III) chloride; sodium iodide In acetonitrile for 0.116667h; Ambient temperature;98%
With oxygen; SiO2-Cl In dichloromethane at 0℃; for 0.166667h;98%
74-96-4

ethyl bromide

17356-08-0

thiourea

110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With sodium carbonate In water; acetonitrile at 80℃; for 3h; Sealed tube;89%
64-67-5

diethyl sulfate

110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With sodium disulfide; tetrabutylammomium bromide at 60 - 70℃; for 3h; Reagent/catalyst;95.3%
75-03-6

ethyl iodide

110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With sodium sulfide; sulfur In chloroform; water at 25℃; for 2h;95%
With (C6H5CH2N(Et)3)6Mo7S24 In chloroform at 20℃; for 6h;92%
With diethyl ether; sodium disulfide
With carbon disulfide; potassium hydroxide In dimethyl sulfoxide for 2h;0.6 g
34695-11-9

3,4-dichloro-5-ethylsulfanyl-2(5H)-furanone

A

110-81-6

Diethyl disulfide

B

32978-39-5

4-chloro-5-ethoxy-2(5H)-furanone

Conditions
ConditionsYield
With N,N,N,N-tetraethylammonium tetrafluoroborate; acetic acid In acetonitrile at 21.84℃; for 4.66667h; Electrolysis; Irradiation;
811-51-8

sodium thioethylate

110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With bromonitromethane In methanol85%
With water; iodine
With sulfur
With sulfuryl dichloride; water
With iodine
10147-36-1

n-propanesulfonyl chloride

75-08-1

ethanethiol

A

110-81-6

Diethyl disulfide

B

2043-79-0

propane-1-thiosulfonic acid S-ethyl ester

Conditions
ConditionsYield
With triethylamine In diethyl ether at 20℃; for 0.333333h; Sonication;A 34 %Chromat.
B 13 %Chromat.
80-40-0

ethyl ester of p-toluenesulfonic acid

110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With sodium carbonate; sulfur; thiourea In water at 70℃; for 4h; Green chemistry;87%
With water; sodium disulfide at 110℃;
934478-83-8

2-[bis(ethylsulfanyl)methyl]-1-(2-ethylthioethyl)-5-phenylpyrrole

75-08-1

ethanethiol

A

1-(2-ethylthioethyl)-2-ethylthiomethyl-5-phenylpyrrole

B

110-81-6

Diethyl disulfide

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile) In benzene at 75℃; for 6h;A 80%
B n/a

Ethyl disulfide Chemical Properties

Product Name: Diethyldisulfide (CAS NO.110-81-6)


Molecular Formula: C5H16NNaO3S2
Molecular Weight: 225.31g/mol
Mol File: 110-81-6.mol
Einecs: 205-710-6
Appearance: Clear colorless to light yellow liquid
Melting Point: 95-98.5 °C(lit.)
Boiling point: 154 °C at 760 mmHg
Storage Temperature: -20°C
Flash Point: 40 °C
Density: 0.993 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.506(lit.)
Surface Tension: 32.5 dyne/cm
Enthalpy of Vaporization: 37.58 kJ/mol
Vapour Pressure: 4.17 mmHg at 25°C
XLogP3-AA: 1.6
Product Categories: Sulfide Flavor

Ethyl disulfide Production

 Diethyldisulfide (CAS NO.110-81-6) is the preparation method is the first release within the reactor sodium sulfide solution, according to sodium sulfide: sulfur = 1:1 (molar ratio) is expected to vote put sulfur powder, jacket temperature, in the stirring, when the temperature reached 80 ~ 95 °C when the Serve warm 1h disulfide disodium salt (Na2S2) solution, and then pumped into the alkylation reactor in disulfide disodium salt solution, start stirring until the reaction vessel to a vacuum (2 ~ 3.3) × 104Pa off valves start the chlorine into the ethane, the reaction temperature was controlled at 75 ~ 90 °C, pressure control (1.17 ~ 1.18) × 105Pa, feed ratio (mole ratio) disulfide disodium salt: ethyl = 1:2, Tung finished chloroethane, the will be expected to cool to below 50 °C will be expected to put it aside for the oil pumped to the water separator layer, the upper reservoir shall be finished.

Ethyl disulfide Toxicity Data With Reference

1.    

skn-rbt 500 mg/24H MLD

    28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,171.
2.    

eye-rbt 100 mg/24H MOD

    28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,171.
3.    

orl-rat LD50:2030 mg/kg

    28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,171.

Ethyl disulfide Consensus Reports

Reported in EPA TSCA Inventory.

Ethyl disulfide Safety Profile

Safety Information of Diethyldisulfide (CAS NO.110-81-6):
Hazard Codes: Xn,Xi
Risk Statements: 22-38-41-36/37/38-10 
10:  Flammable
22:  Harmful if swallowed
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin 
41:  Risk of serious damage to eyes
Safety Statements: 26-39-37/39-16-36
16:  Keep away from sources of ignition - No smoking
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing  
37:  Wear suitable gloves  
39:  Wear eye/face protection

Ethyl disulfide Specification

 Diethyldisulfide ,its CAS NO. is 110-81-6,the synonyms is (C2h5s)2 ; 1-(Ethyldisulfanyl)ethane ; Diethyldisulfid ; Disulfide,diethyl ; Dlethyldisulfide ; Ethyldisulfanyl-ethane ; Ethyldisulphide ; Ethyldithioethan .

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