Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Guanfacine hydrochloride

Related Products

Hot Products

Name

Guanfacine hydrochloride

EINECS 249-443-3
CAS No. 29110-48-3 Density N/A
PSA 78.97000 LogP 3.53850
Solubility N/A Melting Point 215-217℃
Formula C9H9 Cl2 N3 O . Cl H Boiling Point N/A
Molecular Weight 282.557 Flash Point N/A
Transport Information N/A Appearance N/A
Safety Poison by ingestion, subcutaneous and intravenous routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl. Risk Codes N/A
Molecular Structure Molecular Structure of 29110-48-3 (GUANFACINE HCL) Hazard Symbols N/A
Synonyms

Benzeneacetamide,N-(aminoiminomethyl)-2,6-dichloro-, monohydrochloride (9CI);2,6-Dichlorophenylacetylguanidine hydrochloride;BS 100-141;Estulic;Guanfacine hydrochloride;LON 798;N-Amidino-2-(2,6-dichlorophenyl)acetamidehydrochloride;SPD 503;Tenex;Tenex (pharmaceutical);[(2,6-Dichlorophenyl)acetyl]guanidine monohydrochloride;

Article Data 2

Guanfacine hydrochloride Synthetic route

54551-83-6

methyl 2-(2,6-dichlorophenyl)acetate

50-01-1

guanidine hydrochloride

29110-48-3

guanfacine hydrochloride

Conditions
ConditionsYield
In ethanol at 20℃; for 30h;15%
29110-47-2

guanfacine

29110-48-3

guanfacine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water for 0.5h; pH=1;32.6 g
1364788-93-1

C21H30N4O9

29110-48-3

guanfacine hydrochloride

1364788-95-3

C26H34Cl2N6O7

Conditions
ConditionsYield
With 4-methyl-morpholine In N,N-dimethyl-formamide at 22℃;84%
24424-99-5

di-tert-butyl dicarbonate

29110-48-3

guanfacine hydrochloride

1364788-99-7

guanfacine tert-butyl carbamate

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 22℃;78%
1364788-77-1

C23H27NO6Si

29110-48-3

guanfacine hydrochloride

1364788-79-3

guanfacine [2-(tert-butyl-diphenyl-silanyloxy)-ethyl] carbamate

Conditions
ConditionsYield
Stage #1: guanfacine hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 22℃; for 0.166667h;
Stage #2: C23H27NO6Si In N,N-dimethyl-formamide at 22℃;
75%
1364788-82-8

C24H29NO6Si

29110-48-3

guanfacine hydrochloride

1364788-84-0

guanfacine [3-(tert-butyl-diphenyl-silanyloxy)-propyl]carbamate

Conditions
ConditionsYield
Stage #1: guanfacine hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 22℃; for 0.166667h;
Stage #2: C24H29NO6Si In N,N-dimethyl-formamide at 22℃;
61%
20412-38-8

neopentyl chloroformate

29110-48-3

guanfacine hydrochloride

1364788-31-7

1-{N'-[2-(2,6-dichloro-phenyl)-acetyl]-guanidinocarbonyloxy}-2,2-dimethylpropane hydrochloride

Conditions
ConditionsYield
With 4-methyl-morpholine In tetrahydrofuran at 22℃; Inert atmosphere;34%
959425-11-7

cyclopropylmethyl 2,5-dioxopyrrolidin-1-yl carbonate

29110-48-3

guanfacine hydrochloride

1364788-87-3

{N'-[2-(2,6-dichloro-phenyl)acetyl]-guanidino-carbonyloxy}methylcyclopropane

Conditions
ConditionsYield
Stage #1: guanfacine hydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 22℃; for 0.166667h;
Stage #2: cyclopropylmethyl 2,5-dioxopyrrolidin-1-yl carbonate In N,N-dimethyl-formamide at 22℃;
33%
29110-48-3

guanfacine hydrochloride

543-27-1

isobutyl chloroformate

1364788-29-3

1-{N'-[2-(2,6-dichloro-phenyl)-acetyl]-guanidinocarbonyloxy}-2-methylpropane hydrochloride

Conditions
ConditionsYield
With 4-methyl-morpholine In tetrahydrofuran at 22℃; Inert atmosphere;29%
14602-86-9

(1R,2S,5R)-menthyl chloroformate

29110-48-3

guanfacine hydrochloride

1364788-66-8

1-(R)-{N'-[2-(2,6-dichloro-phenyl)-acetyl]-guanidinocarbonyloxy}-2-(S)-isopropyl-5-(R)-methyl-cyclohexane hydrochloride

Conditions
ConditionsYield
With 4-methyl-morpholine In tetrahydrofuran at 22℃; Inert atmosphere;28%

Guanfacine hydrochloride Specification

The Guanfacine hydrochloride, with the CAS registry number 29110-48-3,is also known as N-(Aminoiminomethyl)-2,6-dichlorophenylacetamide monohydrochloride. It belongs to the product categories of Amines;Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor. This chemical's molecular formula is C9H9Cl2N3O.HCl and molecular weight is 282.55.Its EINECS number is 249-443-3. What's more,Its systematic name is Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-,monohydrochloride. It is a centrally acting antihypertensive agent. The drug lowers both systolic and diastolic blood pressure by activating the central nervous system alpha-2 adrenoreceptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation.

Physical properties about Guanfacine hydrochloride are:
(1)ACD/LogP:  1.606; (2)# of Rule of 5 Violations:  0; (3)ACD/LogD (pH 5.5):  1.40; (4)ACD/LogD (pH 7.4):  1.60; (5)ACD/BCF (pH 5.5):  6.08; (6)ACD/BCF (pH 7.4):  9.71; (7)ACD/KOC (pH 5.5):  110.61; (8)ACD/KOC (pH 7.4):  176.75; (9)#H bond acceptors:  4; (10)#H bond donors:  4; (11)#Freely Rotating Bonds:  3; (12)Flash Point:  210.8 °C; (13)Enthalpy of Vaporization:  67.95 kJ/mol ; (14)Boiling Point:  424.9 °C at 760 mmHg; (15)Vapour Pressure:  2E-07 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:Clc1cccc(Cl)c1CC(=O)\N=C(/N)N.Cl;
(2)Std. InChI:InChI=1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H;
(3)Std. InChIKey:DGFYECXYGUIODH-UHFFFAOYSA-N.

The toxicity data of Guanfacine hydrochloride are as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 25mg/kg (25mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4511, 1980.
mouse LD50 oral 15300ug/kg (15.3mg/kg)   Drugs in Japan Vol. -, Pg. 372, 1995.
mouse LD50 subcutaneous 46mg/kg (46mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4511, 1980.
rat LD50 intravenous 5800ug/kg (5.8mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4511, 1980.
rat LD50 oral 142mg/kg (142mg/kg)   Drugs in Japan Vol. -, Pg. 372, 1995.
rat LD50 subcutaneous 114mg/kg (114mg/kg) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 4511, 1980.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 29110-48-3