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iopromide
Conditions | Yield |
---|---|
With sodium methylate In methanol at 75℃; for 8h; | 100% |
Stage #1: C26H32I3N3O12 With sodium hydroxide at 50℃; for 4h; Stage #2: With hydrogenchloride pH=2-3; | 99% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine Large scale; | 95% |
3-Amino-1,2-propanediol
iopromide
Conditions | Yield |
---|---|
With sodium carbonate In N,N-dimethyl acetamide at 20℃; for 2h; | 92% |
C18H27N3O8
iopromide
Conditions | Yield |
---|---|
In water at 70 - 90℃; for 6h; | 88.1% |
With Iodine monochloride In water at 70 - 85℃; for 3h; Temperature; Concentration; | 82.3 g |
iopromide
Conditions | Yield |
---|---|
With sodium hydroxide at 20℃; for 5h; | 86% |
5-methoxyacetylamino-2,4,6-triiodoisophthalic acid [(2,3-dihydroxy-N-methylpropyl)-(2,3-diacetoxypropyl)]diamide
iopromide
Conditions | Yield |
---|---|
With water; sodium hydroxide In N,N-dimethyl acetamide at 20 - 25℃; for 10h; | 85% |
With water; sodium hydroxide at 20 - 25℃; for 10h; Industry scale; |
iopromide
Conditions | Yield |
---|---|
With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide In acetone at 20℃; for 13h; | 85% |
With osmium(VIII) oxide; 4-methylmorpholine N-oxide In water; acetone at 20℃; for 12h; | 55.8 g |
iopromide
Conditions | Yield |
---|---|
With water; sodium hydroxide at 50℃; for 0.5h; | 85% |
With sodium hydroxide In water at 20 - 50℃; for 0.5h; | 85% |
iopromide
Conditions | Yield |
---|---|
With sodium hydroxide at 20℃; for 3h; | 80% |
iopromide
Conditions | Yield |
---|---|
With sodium hydroxide at 0 - 50℃; | 80% |
The Iopromide, with the CAS registry number 73334-07-3, is also known as 1,3-Benzenedicarboxamide,N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N1-methyl-. It belongs to the product categories of Amines; Aromatics; Diagnostic; Intermediates & Fine Chemicals; Pharmaceuticals; Isotope Labelled Compounds. Its EINECS number is 277-385-9. This chemical's molecular formula is C18H24I3N3O8 and molecular weight is 791.11. What's more, its systematic name is N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methylisophthalamide. Its classification codes are: (1)Contrast Media; (2)Diagnostic aid [radiopaque medium]; (3)Drug / Therapeutic Agent. It is a kind of labelled Iopromide and is nonionic, injectable radio-contrast medium.
Physical properties of Iopromide are: (1)ACD/LogP: -2.658; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): -2.66; (4)ACD/LogD (pH 7.4): -2.66; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 11; (10)#H bond donors: 6; (11)#Freely Rotating Bonds: 15; (12)Polar Surface Area: 168.66 Å2; (13)Index of Refraction: 1.71; (14)Molar Refractivity: 142.217 cm3; (15)Molar Volume: 364.044 cm3; (16)Polarizability: 56.379×10-24cm3; (17)Surface Tension: 78.01 dyne/cm; (18)Density: 2.173 g/cm3; (19)Flash Point: 462.376 °C; (20)Enthalpy of Vaporization: 128.074 kJ/mol; (21)Boiling Point: 840.927 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: Ic1c(c(I)c(c(I)c1NC(=O)COC)C(=O)NCC(O)CO)C(=O)N(CC(O)CO)C
(2)Std. InChI: InChI=1S/C18H24I3N3O8/c1-24(4-9(28)6-26)18(31)12-13(19)11(17(30)22-3-8(27)5-25)14(20)16(15(12)21)23-10(29)7-32-2/h8-9,25-28H,3-7H2,1-2H3,(H,22,30)(H,23,29)
(3)Std. InChIKey: DGAIEPBNLOQYER-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | > 21gm/kg (21000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 44, Pg. 1275, 1994. | |
mouse | LD50 | intravenous | 34gm/kg (34000mg/kg) | AJNR, American Journal of Neuroradiology. Vol. 4, Pg. 350, 1983. | |
rat | LD50 | intravenous | 21403mg/kg (21403mg/kg) | Acta Radiologica, Supplementum. Vol. 370, Pg. 41, 1987. |