Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
L-Norvaline methyl ester hydrochloride |
EINECS | 1533716-785-6 |
CAS No. | 56558-30-6 | Density | N/A |
PSA | 52.32000 | LogP | 1.78910 |
Solubility | N/A | Melting Point |
N/A |
Formula | C6H14ClNO2 | Boiling Point | 197.5 °C at 760 mmHg |
Molecular Weight | 167.636 | Flash Point | 73.2 °C |
Transport Information | N/A | Appearance | N/A |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
L-Norvaline,methyl ester, hydrochloride (9CI);Methyl L-norvalinate hydrochloride; |
Article Data | 17 |
Conditions | Yield |
---|---|
With hydrogenchloride Ambient temperature; | 98% |
With hydrogenchloride for 1h; Reflux; | 98% |
With hydrogenchloride for 6h; Reflux; Inert atmosphere; | 97% |
tert-butyl-(2S,3S)-1,2-dihydroxyhexan-3-ylcarbamate
methyl L-norvalinate hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NaIO4; RuCl3*3H2O / acetonitrile; CCl4; H2O / 2 h 1.2: 65 percent / 3N HCl / tetrahydrofuran / 12 h / Heating 2.1: SOCl2 / 60 h / Heating View Scheme |
Conditions | Yield |
---|---|
In methanol for 19h; Heating / reflux; |
L-Norvaline
methyl L-norvalinate hydrochloride
Conditions | Yield |
---|---|
In methanol |
Conditions | Yield |
---|---|
With thionyl chloride at 40℃; Cooling with ice; |
(2S,4R)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carboxylic acid
methyl L-norvalinate hydrochloride
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2.5h; | 95% |
di-tert-butyl dicarbonate
methyl L-norvalinate hydrochloride
methyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-norvalinate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 93% |
N-tert-butyloxy-isoleucine
methyl L-norvalinate hydrochloride
Conditions | Yield |
---|---|
With 1-[bis(dimethylamino)methylen]-1-H-benzotriazolim-tetrafluoroborate-3-oxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; | 92% |
With triethylamine; diethyl dicarbonate In N,N-dimethyl-formamide at 0 - 20℃; for 2.5h; | 74% |
methyl L-norvalinate hydrochloride
trifluoroacetic anhydride
(S)-methyl 2-(2,2,2-trifluoroacetamido)pentanoate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 23℃; for 5h; | 89% |
With 4-methyl-morpholine In chloroform |
methyl L-norvalinate hydrochloride
5-(cyclopropanecarbonyl)-2,2-dimethyl-1,3-dioxane-4,6-dione
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane at 110℃; for 4h; | 86% |
The L-Norvaline methyl ester hydrochloride, with the CAS registry number 56558-30-6, is also known as (S)-2-Amino-pentanoic acid methyl ester hydrochloride. This chemical's molecular formula is C6H14ClNO2 and molecular weight is 167.63. What's more, its systematic name is called Methyl L-norvalinate hydrochloride.
Physical properties about L-Norvaline methyl ester hydrochloride are: (1) ACD/LogP: 0.58; (2) # of Rule of 5 Violations: 0; (3) #H bond acceptors: 3; (4) #H bond donors: 2; (5) #Freely Rotating Bonds: 5; (6) Polar Surface Area: 52.32 Å2; (7) Flash Point: 73.2 °C; (8) Enthalpy of Vaporization: 44.25 kJ/mol; (9) Boiling Point: 197.5 °C at 760 mmHg; (10) Vapour Pressure: 0.319 mmHg at 25 °C.
You can still convert the following datas into molecular structure:
(1)SMILES: CCC[C@H](N)C(=O)OC.Cl
(2)InChI: InChI=1/C6H13NO2.ClH/c1-3-4-5(7)6(8)9-2;/h5H,3-4,7H2,1-2H3;1H/t5-;/m0./s1
(3)InChIKey: IODNYRVZHKRFIW-JEDNCBNOBF