Reference

Protective effect of ammonium ions and L-norvaline on galactosamine induced liver injury

Protective effect of ammonium ions and L-norvaline on galactosamine induced liver injury. Pausch, Juergen; Wohleb, Beate; Gerok, Wolfgang (Med. Klin., Univ. Freiburg, Freiburg/Br., Ger.). Hoppe-Seyler's Z. Physiol. Chem., 358(5), 595-7 (English) 1977. CODEN: HSZPAZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) NH4+ (as NH4OAc) and L-norvaline [6600-40-4] protected rats from galactosamine [7535-00-4] hepatitis by counteracting the galactosamine-induced deficiency in uridine phosphates. Liver damage from galactosamine was indicated by a leakage of cytoplasmic and mitochondrial enzymes and by a decrease in liver glycogen, and all of these effects were suppressed by i.p. treatment with NH4+ or norvaline prior to i.p. galactosamine. NH4+ and norvaline acted by causing an accumulation and subsequent efflux of mitochondrial carbamoyl phosphate, resulting in increased de novo pyrimidine nucleotide synthesis.

Studies on the Maillard reaction

Studies on the Maillard reaction. Part 14. Stereoselective reactions during the nonenzymic browning. Westphal, G.; Kroh, L.; Bochow, C. (Sekt. Nahrungsgueterwirts., Humboldt-Univ., Berlin, Ger. Dem. Rep.). Nahrung, 28(2), K9-K11 (German) 1984. CODEN: NAHRAR. ISSN: 0027-769X. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) In model nonenzymic browning systems contg. D-glucose [50-99-7] with D-methionine [348-67-4], L-methionine [63-68-3], D-norvaline [2013-12-9], L-norvaline [6600-40-4], D-phenylalanine [673-06-3], L-phenylalanine [63-91-2], D-a-alanine [338-69-2], or L-a-alanine [56-41-7], stereoselectivity was obsd., the glucose reacting earlier with the D-isomer in each case. Quickest reaction was with D-phenylalanine (<5 h) and slowest with L-norvaline (~15 h) at 100° in these water-contg. model systems.