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6-hydrazino-1,3-dimethyl-1H-pyrimidine-2,4-dione
Benzylidenemalononitrile
A
1,7-Dihydro-5,7-dimethyl-3-phenyl-4H-pyrazolo<3,4-d>pyrimidin-4,6(5H)-dion
B
Benzylmalononitrile
C
malononitrile
Conditions | Yield |
---|---|
In propan-1-ol for 2h; Heating; | A 90% B 97% C 90% |
6-hydrazino-1,3-dimethyl-1H-pyrimidine-2,4-dione
2-cyano-3-phenylacrylamide
A
1,7-Dihydro-5,7-dimethyl-3-phenyl-4H-pyrazolo<3,4-d>pyrimidin-4,6(5H)-dion
B
Benzylmalononitrile
C
malononitrile
Conditions | Yield |
---|---|
In propan-1-ol for 2h; Heating; | A 90% B 97% C 90% |
6-hydrazino-1,3-dimethyl-1H-pyrimidine-2,4-dione
ethyl benzylidenecyanoacetate
A
1,7-Dihydro-5,7-dimethyl-3-phenyl-4H-pyrazolo<3,4-d>pyrimidin-4,6(5H)-dion
B
Benzylmalononitrile
C
malononitrile
Conditions | Yield |
---|---|
In propan-1-ol for 2h; Heating; | A 90% B 97% C 90% |
Conditions | Yield |
---|---|
With sodium iodide In dimethyl sulfoxide at 150℃; for 15h; Temperature; Sealed tube; Inert atmosphere; | 95.14% |
Conditions | Yield |
---|---|
With potassium iodide at 160℃; for 8h; Sealed tube; Inert atmosphere; | 95.01% |
3-(Chloromethyl)-2-benzoxazolinethione
potassium cyanide
A
3-<(2-Benzoxazolyl)thiomethyl>-2(3H)-benzoxazolethione
B
malononitrile
Conditions | Yield |
---|---|
In acetone for 24h; Product distribution; Mechanism; Heating; | A 95% B n/a |
Conditions | Yield |
---|---|
With pyridine; phosgene In 1,2-dichloro-ethane at 75℃; for 15h; Solvent; Temperature; Reagent/catalyst; | 94% |
With phosgene; trichlorophosphate at 70 - 73℃; for 5 - 7h; Temperature; | 93.59% |
With pyridine; trichlorophosphate In water | 76% |
Conditions | Yield |
---|---|
With pyridine In 1,2-dichloro-ethane at 75℃; for 15h; Reagent/catalyst; Solvent; Temperature; | 94% |
3-chloromethyl-3H-benzothiazole-2-thione
potassium cyanide
A
3-<(2-Benzothiazolyl)thiomethyl>-2(3H)-benzothiazolethione
B
malononitrile
Conditions | Yield |
---|---|
In acetone for 24h; Product distribution; Mechanism; Heating; | A 92% B n/a |
Conditions | Yield |
---|---|
With potassium iodide at 155℃; for 12h; Sealed tube; Inert atmosphere; | 91.04% |
Malononitrile(109-77-3) is a nitrile and it is also called propanedinitrile with formula CH2(CN)2. Malononitrile(109-77-3)'s Pka in water is 11, which is relatively acidic. malononitrile(109-77-3) is used as a suitable starting material for the Gewald reaction, in related chemistry. In Gewald reaction, a 2-aminothiophenethe is produced by nitrile condenses with a ketone or aldehyde in the presence of elemental sulfur and a base.
Product Name:Malononitrile
CAS No:109-77-3
Synonyms:AKOS BBS-00004370;METHYLENE DICYANIDE;METHYLENE CYANIDE;MALONODINITRILE;MALONITRILE;MALONONITRILE;MALONIC ACID DINITRILE;MDN
Molecular Formula:C3H2N2
Formula Weight:66.06
Density:1.049 g/mL at 25 °C(lit.)
Melting Point:30-32 °C(lit.)
Boiling Point:220 °C(lit.)
Refractive Index:1.4150
Flash Point:234 °F
Molecular Structure:
1. Malononitrile is used in the Knoevenagel condensation, such as CS gas' preparation.
2. malononitrile is used as a suitable starting material for the Gewald reaction in related chemistry. In Gewald reaction, the nitrile condenses with a ketone or aldehyde in the presence of elemental sulfur and a base to produce a 2-aminothiophene.
1. | eye-rbt 5 mg/24H SEV | 85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,899. | ||
2. | orl-rat LD50:60,800 μg/kg | 28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,158. | ||
3. | skn-rat LD50:350 mg/kg | MEPAAX Medycyna Pracy. Industrial Medicine. 27 (1976),1. | ||
4. | LD50:20,550 μg/kg | MEPAAX Medycyna Pracy. Industrial Medicine. 27 (1976),1. | ||
5. | scu-rat LD50:31,500 μg/kg | . 27 (1976),1. | ||
orl-mus LD50:19 mg/kg | KHZDAN Khigiena i Zdraveopazvane. 9 (1966),50. | |||
7. | scu-rat LDLo:7 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 3 (1897),77. | ||
8. | ipr-mus LD50:13 mg/kg | NATUAS Nature. 228 (1970),1315. | ||
LDLo:8 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 3 (1897),77. | |||
10. | ivn-mus |