- Methotrexate
- Methotrexate hydrate
- METHOTREXATE SODIUM
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| Name |
METHOTREXATE SODIUM |
EINECS | 239-495-5 |
| CAS No. | 15475-56-6 | Density | g/cm3 |
| PSA | 213.37000 | LogP | 0.48700 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C20H22 N8 O5 . x Na | Boiling Point | °Cat760mmHg |
| Molecular Weight | 498.409 | Flash Point | °C |
| Transport Information | N/A | Appearance | Orange to yellow crystalline powder |
| Safety | Poison by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Na2O and NOx. See also METHOTREXATE. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Glutamicacid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, sodiumsalt, L-(+)- (8CI); L-Glutamic acid,N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, sodium salt(9CI); Abitrexate; Methotrexate sodium; Methotrexate sodium salt; SodiumL-(+)-methotrexate |
METHOTREXATE SODIUM Chemical Properties
Product Name: Methotrexate sodium (CAS NO.15475-56-6)
Molecular Formula: C20H21N8NaO5
Molecular Weight: 476.48g/mol
Mol File: 15475-56-6.mol
Einecs: 239-495-5
Appearance: Orange to yellow crystalline powder
H-Bond Donor: 4
H-Bond Acceptor: 12
METHOTREXATE SODIUM Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 27mg/kg (27mg/kg) | Polish Journal of Pharmacology and Pharmacy. Vol. 25, Pg. 327, 1973. | |
| mouse | LD50 | unreported | 380mg/kg (380mg/kg) | Cancer Treatment Reports. Vol. 66, Pg. 351, 1982. |
METHOTREXATE SODIUM Safety Profile
Poison by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Na2O and NOx. See also METHOTREXATE.
METHOTREXATE SODIUM Specification
Methotrexate sodium ,its CAS NO. is 15475-56-6,the synonyms is Methotrexate sodium for injection ; Mtx sodium ; n-[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]-l-glutamic acid hydrogen 1-sodium salt ; n-[4-[[(2,4-Diaminopteridine-6-yl)methyl]methylamino]benzoyl]-l-glutamic acid/sodium,(1:x) salt .
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