- Methyl 1-Benzyl-5-oxopyrrolidine-3-carboxylate
- Methyl (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6E)-heptenoate
- Methyl (2E)-3-(4-methylphenyl)propenoate
- Methyl (2E)-3-cyclohexylprop-2-enoate
- Methyl (2R)-2-[(tert-butoxycarbonyl)amino]-3-iodopropanoate
- Methyl (2R)-2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate
- Methyl (2R)-2-amino-2-cyclohexylethanoate hydrochloride
- Methyl (2R)-2-bromo-2-(2-chlorophenyl)acetate
- Methyl (2R,3S)-3-(4-methoxyphenyl)-2-oxiranecarboxylate
- Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate
- 289042-12-2Tert-butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
- 289054-34-8Ergosta-5,24(28)-diene-3,7,16-triol,(3b,7a,16b)- (9CI)
- 28905-44-4[(2R)-2-[(2R,3S)-3,4-dihydroxyoxolan-2-yl]-2-dodecanoyloxy-ethyl] dodecanoate
- 289056-24-2Stigmast-5-ene-3,7,16-triol,(3b,7a,16b,24x)- (9CI)
- 289058-20-4Benzofuran,4-chloro-2,3-dihydro-
- 2890-96-2Bicyclo[2.2.1]hept-5-ene-2-carbonitrile,(1R,2S,4R)-rel-
- 28911-01-54H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine,8-chloro-6-(2-chlorophenyl)-1-methyl-
- 28916-38-35-Hexen-3-yn-1-ol
- 28917-43-3Benzoic acid,3,5-bis(phenylmethoxy)-
- 28920-43-69-Fluorenylmethyl chloroformate
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
Methyl 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carboxylate |
EINECS | 608-290-6 |
| CAS No. | 289042-11-1 | Density | 1.305 g/cm3 |
| PSA | 97.84000 | LogP | 3.66930 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C17H20FN3O4S | Boiling Point | 551.956 °C at 760 mmHg |
| Molecular Weight | 381.428 | Flash Point | 287.613 °C |
| Transport Information | N/A | Appearance | White or off-white powder |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidine-5-carboxylicacid methyl ester;Rosuvastatin intermediate R-1-1;(Carboxylate) 4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl amino)pyrimidine-5-carboxylate;4-(4-Fluorophenyl)-6-isopropyl-2-(n-methyl-N-methylsulfonylamino)pyrimidine-5-carboxylate; |
Article Data | 11 |
Methyl 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carboxylate Synthetic route
- 1184-85-6
N-methylmethane sulphonamide
- 289042-11-1
methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: methyl 4-(4-fluorophenyl)-2-hydroxy-6-isopropylpyrimidine-5-carboxylate With potassium carbonate; p-toluenesulfonyl chloride In acetic acid butyl ester at 45℃; for 0.5h; Stage #2: N-methylmethane sulphonamide With potassium carbonate In acetic acid butyl ester at 125℃; for 3h; | 94% |
- 1184-85-6
N-methylmethane sulphonamide
- 488798-38-5
2-chloro-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid methyl ester
- 289042-11-1
methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: N-methylmethane sulphonamide With sodium hydride In acetonitrile; mineral oil for 0.0833333h; Stage #2: 2-chloro-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid methyl ester In acetonitrile; mineral oil for 7h; Reagent/catalyst; Solvent; Reflux; | 93.2% |
- 799842-06-1
4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylic acid methyl ester
- 41881-75-8
sodium salt of N-methyl-N-methylsulfonylamine
- 289042-11-1
methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate
| Conditions | Yield |
|---|---|
| In N,N-dimethyl-formamide at 30℃; for 1h; | 92.42% |
- 799842-06-1
4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylic acid methyl ester
- 1184-85-6
N-methylmethane sulphonamide
- 289042-11-1
methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetonitrile at 25 - 85℃; for 2.5 - 3h; Product distribution / selectivity; Heating / reflux; | 87.93% |
| With potassium carbonate In acetic acid butyl ester at 90℃; for 3h; Product distribution / selectivity; |
- 160009-36-9
methyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carboxylate
- 124-63-0
methanesulfonyl chloride
- 289042-11-1
methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate
| Conditions | Yield |
|---|---|
| Stage #1: methyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carboxylate With sodium tert-pentoxide In 1,2-dimethoxyethane at 20℃; for 1h; Inert atmosphere; Stage #2: methanesulfonyl chloride In 1,2-dimethoxyethane at -10℃; for 1h; | 78% |
| Stage #1: methyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carboxylate With sodium tert-pentoxide In 1,2-dimethoxyethane at 20℃; for 0.5h; Stage #2: methanesulfonyl chloride In 1,2-dimethoxyethane at -10℃; for 0.5h; | 76% |
| With n-butyllithium In tetrahydrofuran; hexane at -75 - -70℃; | 63% |
| Stage #1: methyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidine-5-carboxylate With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: methanesulfonyl chloride In N,N-dimethyl-formamide for 1h; Product distribution / selectivity; |
- 14593-46-5
sodium tert-pentoxide
- 506-77-4
cyanogen chloride
- 289042-11-1
methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate
| Conditions | Yield |
|---|---|
| In water | 74.1% |
- 1184-85-6
N-methylmethane sulphonamide
- 506-77-4
cyanogen chloride
- 289042-11-1
methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate
| Conditions | Yield |
|---|---|
| With sodium t-butanolate In methanol; water; tert-butyl alcohol | 56.3% |
| In N,N-dimethyl acetamide; water; acetone | 29% [concentration (GC) |
| In N,N-dimethyl acetamide; water; acetone | 30.2% [concentration (GC) |
| In water; acetone |
- 317806-76-1
N-cyano-N-methylmethanesulphonamide
- 1184-85-6
N-methylmethane sulphonamide
- 289042-11-1
methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate
| Conditions | Yield |
|---|---|
| With sodium t-butanolate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; tert-butyl alcohol | 52.1% |
- 317806-76-1
N-cyano-N-methylmethanesulphonamide
- 289042-11-1
methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate
| Conditions | Yield |
|---|---|
| In N,N-dimethyl acetamide; water | 27% |
| In N,N-dimethyl acetamide; water | |
| titanium tetrachloride In water; toluene | 13.5% [concentration (HPLC) |
- 1184-85-6
N-methylmethane sulphonamide
- 127-19-5
N,N-dimethyl acetamide
- 506-77-4
cyanogen chloride
- 289042-11-1
methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methanesulphonyl-N-methylamino)pyrimidine-5-carboxylate
| Conditions | Yield |
|---|---|
| In water | 22% |
Methyl 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carboxylate Chemical Properties
.jpg)
Systematic Name: Methyl 4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidine-5-carboxylate
Molecular Formula: C17H20FN3O4S
Molecular Weight: 381.42 g/mol
Canonical SMILES: O=S(=O)(N(c1nc(c(c(n1)C(C)C)C(=O)OC)c2ccc(F)cc2)C)C
InChI: InChI=1/C17H20FN3O4S/c1-10(2)14-13(16(22)25-4)15(11-6-8-12(18)9-7-11)20-17(19-14)21(3)26(5,23)24/h6-10H,1-5H3
Product Categories: Intermediatesofrosuvastatincalcium; Rosuvastatin Calcium and its intermediates
Molar Volume: 292.364 cm3
Polarizability: 37.303 10-24 cm3
Surface Tension: 50.963 dyne/cm
Density: 1.305 g/cm3
Flash Point: 287.613 °C
Enthalpy of Vaporization: 83.241 kJ/mol
Boiling Point: 551.956 °C at 760 mmHg
Vapour Pressure of Methyl 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carboxylate (CAS NO.289042-11-1): 0 mmHg at 25 °C
Methyl 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carboxylate Specification
Methyl 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carboxylate (CAS NO.289042-11-1), its Synonyms are 4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidine-5-carboxylic acid methyl ester ; Rosuvastatin intermediate R-1-1 ;4-(4-Fluorophenyl)-6-isopropyl-2-(n-methyl-N-methylsulfonylamino)pyrimidine-5-carboxylate ; (Carboxylate) 4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl amino)pyrimidine-5-carboxylate .
What can I do for you?
Get Best Price
