Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Mianserin hydrochloride

Related Products

Hot Products

Basic Information Post buying leads Suppliers
Name

Mianserin hydrochloride

EINECS 244-426-7
CAS No. 21535-47-7 Density 1.18 g/cm3
PSA 6.48000 LogP 3.88880
Solubility 3.4 mg/mL in water Melting Point >230 °C (dec.)
Formula C18H20N2.HCl Boiling Point 411.3 °C at 760 mmHg
Molecular Weight 300.831 Flash Point 186.1 °C
Transport Information UN 3249 Appearance Off-white solid
Safety 7-16-36/37-45 Risk Codes 22
Molecular Structure Molecular Structure of 21535-47-7 (Mianserin hydrochloride) Hazard Symbols HarmfulXn, IrritantXi
Synonyms

Dibenzo[c,f]pyrazino[1,2-a]azepine,1,2,3,4,10,14b-hexahydro-2-methyl-, monohydrochloride (8CI,9CI);Athymil;Bolvidon;GB 94;Lantanon;Mianserin hydrochloride;NSC 292267;Norval;Org GB 94;Tetramide;Toluon;Tolvin;Tolvon;mianserin HCl;

 

Mianserin hydrochloride Specification

The Bolvidon with the cas number 21535-47-7, is also called (1)1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)-pyrazino(1,2-a)azepine monohydrochloride; (2)1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine hydrochloride; (3) Athymil ; (4) Bolvidon ; (5)Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, monohydrochloride; (6) EINECS 244-426-7 ; (7) GB 94 ; (8) Lerivon ; (9) Mianserin HCl ; (10) Mianserin hydrochloride ; (11) Mianserine hydrochloride ; (12) Norval ; (13) ORG GB 94 ; (14) Tolvin ; (15) Tolvon ; (16) UNII-2X03TN217S. It belongs to Serotonin receptor product categories. 

Properties of Bolvidon are: (1)ACD/LogP: 3.67 ; (2)# of Rule of 5 Violations: 0 ; (3)ACD/LogD (pH 5.5): 1.66 ; (4)ACD/LogD (pH 7.4): 3.29 ; (5)ACD/BCF (pH 5.5): 3.56 ; (6)ACD/BCF (pH 7.4): 151.22 ; (7)ACD/KOC (pH 5.5): 23.21 ; (8)ACD/KOC (pH 7.4): 986.89 ; (9)#H bond acceptors: 2 ; (10)#H bond donors: 0 ; (11)#Freely Rotating Bonds: 0 ; (12)Polar Surface Area: 6.48 Å2 ; (13)Flash Point: 186.1 °C ; (14)Enthalpy of Vaporization: 66.38 kJ/mol; (15)Boiling Point: 411.3 °C at 760 mmHg ; (16)Vapour Pressure: 5.65E-07 mmHg at 25°C

The Bolvidon appears to be white and film coated tablet, and seem to be white or white-Like after removing it's film coat. It is mainly used for treatment with depression. Bolvidon is well tolerated, especially in elderly patients and patients with cardiovascular disease. During treatment, Bolvidon has no anticholinergic effects, nor obvious cardiovascular system reactions. When you are using Bolvidon, please take the following precautions: firstly, daily amount can be taken divided into several time, but the best meal served in bedtime can take time to improve (night sleep). Seconly, when clinical symptoms has improved, it still should maintain the drug therapy for several months. At last, this medicine is water-soluble, and film-coated tablet, swallowed with a few water, and do not chew.

You can still convert the following datas into molecular structure :
1. SMILES: Cl.c42c(N3C(c1ccccc1C2)CN(C)CC3)cccc4
2. InChI: InChI=1/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H

The Bolvidon toxic data can be showed in the following sheet.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LDLo oral 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 56, 1981.
mouse LD50 intraperitoneal 117mg/kg (117mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
mouse LD50 intravenous 31mg/kg (31mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 56, 1981.
mouse LD50 oral 224mg/kg (224mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979.
mouse LD50 subcutaneous 118mg/kg (118mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979.
rat LD50 intraperitoneal 262mg/kg (262mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979.
rat LD50 intravenous 31850ug/kg (31.85mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 484, 1983.
rat LD50 oral 780mg/kg (780mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Pharmacological and Biochemical Properties of Drug Substances. Vol. 3, Pg. 56, 1981.
rat LD50 subcutaneous > 3gm/kg (3000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 31, Pg. 112, 1979.
women TDLo oral 18mg/kg (18mg/kg) BEHAVIORAL: COMA

CARDIAC: PULSE RATE

CARDIAC: OTHER CHANGES
Human Toxicology. Vol. 6, Pg. 401, 1987.
women TDLo oral 28mg/kg/5W (28mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: CHANGE IN RATE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
British Medical Journal. Vol. 284, Pg. 1912, 1982.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 21535-47-7