Miconazole nitrate (22832-87-7),Miconazole nitrate (22832-87-7) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Miconazole nitrate
CAS No.:
22832-87-7
Molecular Structure:
Formula:
C₁₈H₁₅Cl₄N₃O₄
Molecular Weight:
479.16
Deleted CAS:
75319-48-1
Synonyms:
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole; nitric acid;Conofite;[2,4-Dichloro-.beta.-(2, 4-dichlorobenzyloxy)phenethyl]imidazole nitrate;1H-Imidazole,1-[2-(2,4-dichlorophenyl)-2- [(2,4-dichlorophenyl)methoxy]ethyl]-,mononitrate;Gyno-Monistat;Micatin;Imidazole, 1-[2,4-dichloro-.beta.-[ (2, 4-dichlorobenzyl)oxy]phenethyl]-, mononitrate;Florid;1H-Imidazole, 1-[2- (2,4-dichlorophenyl)-2-[(2, 4-dichlorophenyl)methoxy]ethyl]-, mononitrate;Daktarin;Aflorix;Miconazol Nitrate;
EINECS:
245-256-6
Melting Point:
170-185 °C
Boiling Point:
555.1 °C at 760 mmHg
Flash Point:
289.5 °C
Hazard Symbols:
Xn
Risk Codes:
22-43-40
Safety Description:
36/37 Details

Famous Chemical Enterprises

Livzon
Total
Shell
Dupont
Exxonmobil
Akzonobel
Basf
Bayer
BP

Other Products

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Chemistry

Molecular structure of Miconazole nitrate (CAS NO.22832-87-7) is:

Product Name: Miconazole nitrate
CAS Registry Number: 22832-87-7
IUPAC Name: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole ; nitric acid
Molecular Weight: 479.1414 [g/mol]
Molecular Formula: C₁₈H₁₅Cl₄N₃O₄
H-Bond Donor: 1
H-Bond Acceptor: 5
EINECS: 245-256-6
Melting Point:: 170-185 °C
Flash Point: 289.5 °C
Enthalpy of Vaporization: 80.52 kJ/mol
Boiling Point: 555.1 °C at 760 mmHg
Vapour Pressure: 8.55E-12 mmHg at 25°C
Other Registry Number: 75319-48-1
Related Registry Number: 22916-47-8 (Parent)
Product Categories: Active Pharmaceutical Ingredients;Organics;Antifungals for Research and Experimental Use;Biochemistry;API's;Antifungal

Uses

Miconazole nitrate (CAS NO.22832-87-7) is broad-spectrum antifungal drugs,usually used for the treatment of deep fungal infection.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 160mg/kg (160mg/kg)		Chemotherapy Vol. 17(6), Pg. 392, 1972.
guinea pig	LD50	oral	276mg/kg (276mg/kg)		Chemotherapy Vol. 17(6), Pg. 392, 1972.
mouse	LD50	intraperitoneal	480mg/kg (480mg/kg)		Drugs in Japan Vol. 6, Pg. 809, 1982.
mouse	LD50	intravenous	28mg/kg (28mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980.
mouse	LD50	oral	578mg/kg (578mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Chemotherapy Vol. 17(6), Pg. 392, 1972.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 353, 1976.
rat	LD50	intraperitoneal	1060mg/kg (1060mg/kg)		Drugs in Japan Vol. 6, Pg. 809, 1982.
rat	LD50	intravenous	14700ug/kg (14.7mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 181, 1980.
rat	LD50	oral	920mg/kg (920mg/kg)		Drugs in Japan Vol. 6, Pg. 809, 1982.
rat	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 353, 1976.

Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 22-43-40
R22:Harmful if swallowed.
R43:May cause sensitization by skin contact.
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 36/37
S36/37:Wear suitable protective clothing and gloves.
RIDADR: 3249
WGK Germany :3
RTECS: NI4771000
HazardClass: 6.1(b)
PackingGroup: III

Specification

Miconazole nitrate , its cas register number is 22832-87-7. It also can be called 1-(2,4-Dichloro-beta-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole nitrate ; 1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-, mononitrate ; Imidazole, 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)-, mononitrate ; (+-)-Miconazole nitrate .