Detail of "22839-47-0"

MSDS Download
CAS Number:
22839-47-0
Name:
Aspartame
Molecular Structure:
Formula:
C₁₄H₁₈N₂O₅
Molecular Weight:
294.34
Deleted CAS:
7421-84-3|53906-69-7|172964-81-7
Synonyms:
r-Sweet;(3S)-3-amino-3-[[(1S)-1-methoxycarbonyl-2-phenyl-ethyl]carbamoyl]propanoic acid;Sweet cornSweet dipeptide;(3S)-3-azaniumyl-3-[[(1S)-1-methoxycarbonyl-2-phenyl-ethyl]carbamoyl]propanoate;NutraSweet;H-Asp-Phe-OMe;3-amino-3-[(1-methoxycarbonyl-2-phenyl-ethyl)carbamoyl]propanoic acid;L-Phenylalanine,L-R-aspartyl-,2-methyl ester;Aspartame (USAN);Aspartame FCC 4;Succinamic acid, 3-amino-N-(alpha-carboxyphenethyl)-,N-methyl ester;Aspartame FCC4;Aspartame Granula;β-Aspartame;
EINECS:
245-261-3
Density:
1.28 g/cm³
Melting Point:
242-248 °C
Boiling Point:
535.8 °C at 760 mmHg
Flash Point:
277.8 °C
Appearance:
White powder or tablets
Safety:
22-24/25 Details

Famous Chemical Enterprises

Livzon
Total
Shell
Dupont
Exxonmobil
Akzonobel
Basf
Bayer
BP

Reference

Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine: Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Hagiwara, Akihiro; Fukushima, Shoji; Fukushima, Sho; Kitaori, Masayoshi; Shibata, Michiko; Ito, Nobuyuki (Med. Sch., Nagoya City Univ., Nagoya 467, Japan). Gann, 75(9), 763-8 (English) 1984. CODEN: GANNA2. ISSN: 0016-450X. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) The effects of 3 sweeteners, Na saccharin [128-44-9], aspartame [22839-47-0], and stevioside [57817-89-7], on urinary bladder carcinogenesis in rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) [3817-11-6] were evaluated. Male F344 rats were given 0.01% BBN in their drinking water for 4 wk and then the test sweeteners in their diet for 32 wk. All surviving rats were sacrificed after 36 wk, and examd. histol. Treatment with Na saccharin increased the incidence and extent of preneoplastic lesions, papillary or nodular (PN) hyperplasia, in rats treated with BBN for 4 wk. Administration of 5% aspartame or 5% stevioside in the diet did not, however, affect the incidence or extent of PN hyperplasia in BBN-treated rats. No preneoplastic or neoplastic lesions of the urinary bladder were obsd. in rats treated with the test sweeteners only. The results with Na saccharin were consistent with those in previous expts. The data also suggest that aspartame and stevioside do not promote bladder carcinogenesis.

Racemization of aspartic acid and phenylalanine in the sweetener aspartame at 100°C: Racemization of aspartic acid and phenylalanine in the sweetener aspartame at 100°C. Boehm, Marcus F.; Bada, Jeffrey L. (Amino Acid Dat. Lab., Scripps Inst. Oceanogr., La Jolla, CA 92093, USA). Proc. Natl. Acad. Sci. U. S. A., 81(16), 5263-6 (English) 1984. CODEN: PNASA6. ISSN: 0027-8424. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) The racemization half-lives (i.e., the time required to reach a D/L = 0.33) at pH 6.8 for aspartic acid [56-84-8] and phenylalanine [63-91-2] in the sweetener aspartame (L-aspartyl-L-phenylalanine Me ester) [22839-47-0] were 13 and 23 h, resp., at 100°. Racemization at this pH does not occur in aspartame but rather in its diketopiperazine decompn. product. These results indicate that the use of aspartame to sweeten neutral pH foods and beverages that are then heated at elevated temp. could generate D-aspartic acid [1783-96-6] and D-phenylalanine [673-06-3]. At pH 4, a typical pH of most foods and beverages that might be sweetened with aspartame, the half-lives are 47 h for aspartic acid and 1200 h for phenylalanine at 100°. Racemization at pH 4 takes place in aspartame itself. Although the racemization rates at pH 4 are slow and no appreciable racemization of aspartic acid and phenylalanine should occur during the normal use of aspartame, some food and beverage components could conceivably act as catalysts.

Detail of "22839-47-0"

Aspartame

Famous Chemical Enterprises

Related products

Other Products

Supplier Location

Business Type

Certificates

Exhibitions

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

CAS No.22839-47-0 Aspartame

Reference