Welcome to LookChem.com Sign In | Join Free   Post buying lead  Chemical Tools
Post Buying Lead

Basic information

  • Name:

  • Nicotinamide

  • CAS No.:

  • 98-92-0

  • Formula:
  • C6H6N2O
  • Synonyms:
  • Nikotinamid;Nicotylamide;beta-Pyridinecarboxamide;Vitamin B3； Niacin； Niacinmide；;nicotinamide,niacinamide;pyridine-3-carboxamide;Nicobion;Nicotamide;Nicota;Pyridine, 3-carbamoyl-;Amixicotyn;Amide PP;Nicomidol;Delonin Amide;3-Pyridinecarboxamide;NAM;Nicotine acid amide;PP-Faktor;Nicovitol;m-(Aminocarbonyl)pyridine;Nicotinic acid amide;Nicotililamido;Hansamid;Endobion;Vitamin B (VAN);Nicasir;3-Pyridinecarboxylic acid amide;Nicogen;Niacinamide (USP);Nicosan 2;Amnicotin;Pelmine;Nicotinic amide;Savacotyl;Nicofort;Niavit PP;Nicotinamida [INN-Spanish];DEA No. 1405;a-Alanine,N-[(2R)-2,4-dihydroxy-3,3- dimethyl-1-oxobutyl]- [79-83-4] 3-Pyridinecarboxamide;3-Carbamoylpyridine;Niacinamide [USAN];Papulex;Nicotinamide(Vitamin B3);Nikotinsaeureamid [German];Aminicotin;Nicosylamide;Nicovit;

Related products

Other Products

Home > Hot Product_List > Nicotinamide
Supplier Location:
China (Mainland)(86)India(19)United States(14)Japan(3)Canada(2)Switzerland(2)United Kingdom(2)Taiwan(1)Ukraine(1)Venezuela(1)Australia(1)Denmark(1)Korea(1)Netherlands(1)More...
Business Type:
Importer/Exporter(102)Lab/Research institutions(2)Manufacturers(1)Other(1)
Certificates:
ISO(4)Production License(1)

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Chemistry

Molecular Structure of Nicotinamide (CAS NO.98-92-0):

IUPAC Name: pyridine-3-carboxamide
Empirical Formula: C6H6N2O
Molecular Weight: 122.1246
EINECS: 202-713-4
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 33.2Å2
Index of Refraction: 1.57
Molar Refractivity: 33.27 cm3
Molar Volume: 101.3 cm3
Surface Tension: 54.8 dyne/cm
Density: 1.204 g/cm3
Flash Point: 156 °C
Enthalpy of Vaporization: 57.74 kJ/mol
Boiling Point: 334.4 °C at 760 mmHg
Vapour Pressure: 0.000128 mmHg at 25°C
Storage temp: 0-6°C
Form: powder
Color: white
Water Solubility: 1000 g/L (20 ºC)
Merck: 14,6523
BRN: 383619
Stability: Stable. Incompatible with strong oxidizing agents
Melting point: 128-131 °C
Product Categories: Biochemistry; Vitamins; Nutritional Supplements; Vitamins and derivatives; Vitamin Ingredients; Miscellaneous Compounds

Uses

 Niacinamide (CAS NO.98-92-0) is used as food additive, for multivitamin preparations and as intermediate for pharmaceuticals and cosmetics, it is also an inhibitor of sirtuins and has been reported to restore cognition in Alzheimer's Disease transgenic mice, also  has been reported to be an effective skin whitener in topical application.

Production

 For production of niacinamide (CAS NO.98-92-0) in the past, methylethylpyridine was oxidized with nitric acid to yield niacin, and β-picoline was treated with air and ammonia to produce the nitrile that was then hydrolyzed to niacin-amide. A more modem process can produce both niacin and niacinamide (CAS NO.98-92-0) from a single feedstock, either β-picoline or 2-methyl-5-ethylpyridine by oxidative ammonolysis, a combination of oxidation and amination.
 Either niacin or niacinamide (CAS NO.98-92-0) can be selectively isolated from the hydrolysis by varying the hydrolysis time and nitrite concentration. A higher hydrolysis temperature favors production of niacin.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 2500mg/kg (2500mg/kg)   Pharmaceutical Chemistry Journal Vol. 20, Pg. 29, 1986.
mouse LD50 intraperitoneal 2050mg/kg (2050mg/kg)   Radiation Research. Vol. 109, Pg. 479, 1987.
mouse LD50 oral 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. 6, Pg. 545, 1982.
mouse LD50 subcutaneous 2gm/kg (2000mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 19, Pg. 48, 1946.
rat LD50 oral 3500mg/kg (3500mg/kg)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1390, 1986.
rat LD50 subcutaneous 1680mg/kg (1680mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 19, 1946.

Safety Profile

Hazard Codes: Xi
Risk Statements: 36/37/38: Irritating to eyes, respiratory system and skin 
Safety Statements: 26-36-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection.
Nicotinamide rarely causes side effects, and is considered generally safe as a food additive, and as a component in cosmetics and medication.
 

Specification

 Nicotinamide , with CAS number of 98-92-0, can be called Niamide ; Niacinamide/Nicotinamide ; Austrovit PP ; beta.-Pyridinecarboxamide ; Nikotinsaeureamid ; Amid kyseliny nikotinove ; Nicotinamidum ; Pyridine-3-carboxylic acid amide ; Nikotinsaeureamid ; Nicotinamide(Vitamin B3) ; a-Alanine,N-[(2R)-2,4-dihydroxy-3,3- dimethyl-1-oxobutyl]- ; 3-Pyridinecarboxamide ; Nicotinamida ; Niacinamide ; 3-Pyridinecarboxylic acid amide ; Nicotine acid amide . Nicotinamide, also known as niacinamide and Nicotinic acid amide, is the amide of Nicotinic acid (vitamin B3). It is a water-soluble vitamin and is part of the vitamin B group.Nicotinic acid(also known as niacin)can be converte to niacinamide in vivo. It is a white to off white powder.

©2008 LookChem.com,License:ICP NO.：Zhejiang10014259

[Hangzhou]86-571-85317600,85317603,85317620