- Nefopam
- Nefopam Hydrochloride
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Cas Database |
| Name |
Nefopam |
EINECS | 237-148-2 |
| CAS No. | 13669-70-0 | Density | 1.064 g/cm3 |
| PSA | 12.47000 | LogP | 3.17590 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C17H19NO | Boiling Point | 369.526 °C at 760 mmHg |
| Molecular Weight | 253.344 | Flash Point | 109 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine;Fenazoxine;Nefopam; |
Article Data | 8 |
Nefopam Chemical Properties
IUPAC Name: 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine
The MF of 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0) is C17H19NO.
The MW of 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0) is 253.34.
Synonyms of 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0): 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl- ; 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine ; Sinalgico
Product Categories: active pharmaceutical ingredients
Apperance: white crystalline powder of its hydrochloride salt
Index of Refraction: 1.563
EINECS: 237-148-2
Density: 1.064 g/ml
Flash Point: 109 °C
Boiling Point: 369.5 °C
Nefopam Uses
5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0) is non-narcotic analgesic drugs, both the role of muscle relaxants. Applicable to a variety of post-operative pain, cancer pain, visceral smooth muscle cramps and so on.
Nefopam Production
Raw materials: Thionyl chloride-->p-Toluenesulfonic acid-->Hydrogen bromide-->Activated carbon-->Potassium borohydride-->Benzoic acid-->Benzophenone-->PARA TOLUENE-->Benzhydrol
Nefopam Toxicity Data With Reference
| 1. | orl-wmn TDLo:15 mg/kg:CNS,CVS | BMJOAE British Medical Journal. 283 (1981),1508. | ||
| 2. | orl-man TDLo:17 mg/kg:CNS,CVS | BMJOAE British Medical Journal. 283 (1981),1508. | ||
| 3. | orl-rat LD50:178 mg/kg | DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. | ||
| 4. | ivn-rat LD50:28 mg/kg | DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. | ||
| 5. | ims-rat LD50:57 mg/kg | DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. | ||
| 6. | orl-mus LD50:119 mg/kg | DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. | ||
| 7. | ipr-mus LD50:50 mg/kg | DDEVD6 Drug Development and Evaluation. 3 (1979),10. | ||
| 8. | ivn-mus LD50:45 mg/kg | DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. | ||
| 9. | ims-mus LD50:53 mg/kg | DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249. | ||
| 10. |
Nefopam Safety Profile
Poison by ingestion, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: hallucinations, distorted perceptions, excitement, motor activity changes, increased pulse rate without blood pressure fall and heart rate changes. When heated to decomposition it emits toxic fumes of NOx.
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