2-PHENOXYMETHYL-MORPHOLINE

Base Information

• Chemical Name: 2-PHENOXYMETHYL-MORPHOLINE
• CAS No.: 167273-56-5
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Hs Code.: 2934999090
• Mol file: 167273-56-5.mol

Synonyms:Morpholine,2-(phenoxymethyl)-, (?à)-; (R,S)-2-(Phenoxymethyl)morpholine; 2-(Phenoxymethyl)morpholine

Chemical Property of 2-PHENOXYMETHYL-MORPHOLINE

Chemical Property:

• Vapor Pressure: 0.000623mmHg at 25°C
• Refractive Index: 1.505
• Boiling Point: 309.9°Cat760mmHg
• PKA: 8.52±0.40(Predicted)
• Flash Point: 122.9°C
• PSA: 30.49000
• Density: 1.056g/cm³
• LogP: 1.38260
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(Phenoxymethyl)morpholine ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENOXYMETHYL-MORPHOLINE

There total 15 articles about 2-PHENOXYMETHYL-MORPHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-benzyl-2-phenoxymethylmorpholine (1403506-15-9) → (S)-2-(phenoxymethyl)morpholine (661470-52-6,167273-56-5,661470-53-7)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; at 20 ℃; for 1h; Reflux; Cooling with dry ice;

Reference yield:

sulfuric acid mono-(2-amino-ethyl ester) (926-39-6) + Phenyl glycidyl ether (122-60-1,71031-02-2) → 2-[phenoxymethyl]-morpholine (46346-82-1,167273-56-5,661470-53-7)

Guidance literature:

With sodium hydroxide; In methanol; water; toluene;

Reference yield:

4-benzyl-2-(phenoxymethyl)morpholine → 2-[phenoxymethyl]-morpholine (46346-82-1,167273-56-5,661470-53-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 760.051 Torr;

DOI:10.1021/acs.jmedchem.6b01245

upstream raw materials:

Phenyl glycidyl ether

sulfuric acid mono-(2-amino-ethyl ester)

phenol

N-benzyl-2-chloromethylmorpholine

Downstream raw materials:

PL-225B

(S)-ethyl 4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)piperidine-1-carboxylate methanesulfonic acid

(S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid

(S)-3-(2-carbamoyl-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indol-7-ylamino)propanoic acid

Refernces

• 1、 Liu, Yifu,Xie, Zuoquan,Zhao, Dan,Zhu, Jin,Mao, Fei,Tang, Shuai,Xu, Hui,Luo, Cheng,Geng, Meiyu,Huang, Min,Li, Jian. "Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors". . p. 2227 - 2244. Retrieved 2017/04/03.
• 2、 -. "A PROCESS FOR THE PREPARATION OF MORPHOLINO SULFONYL INDOLE DERIVATIVES". . . Retrieved 2012/11/07.