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Progesterone (57-83-0)

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Chemistry

Molecular Structure:

Molecular Formula: C21H30O2
Molecular Weight: 314.46 
CAS NO: 57-83-0
EINECS: 200-350-6 
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 34.14 Å2
Index of Refraction: 1.542
Molar Refractivity: 90.95 cm3
Molar Volume: 288.9 cm3
Surface Tension: 41.1 dyne/cm
Density: 1.08 g/cm3
Flash Point: 166.7 °C
Enthalpy of Vaporization: 70.54 kJ/mol
Boiling Point: 447.2 °C at 760 mmHg
Vapour Pressure: 3.44E-08 mmHg at 25°C
Melting point:  128-132 °C(lit.)
Alpha:  186 º (c=1, ethanol)
Solubility:  H2O: 25 mg/mL, may be clear to slightly hazy
Appearance: Crystalline Powder
Stability: Stable. Incompatible with strong oxidizing agents. 
IUPAC Name: (8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-
dodecahydrocyclopenta[a]phenanthren-3-one
Product Categories of Progesterone (CAS NO.57-83-0): MI;FINISHED MEDICINE;Steroids;ketone;Biochemistry;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor

Uses

 Progesterone (CAS NO.57-83-0) and its analogues have many medical applications, both to address acute situations and to address the long-term decline of natural progesterone levels.

Production

Biosynthesis of  Progesterone (CAS NO.57-83-0) :

Laboratory Synthesis of Progesterone (CAS NO.57-83-0):

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intravenous 100mg/kg (100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968.
rat LD50 intraperitoneal 327mg/kg (327mg/kg)   Drugs in Japan Vol. -, Pg. 1183, 1995.

Consensus Reports
NTP 10th Report on Carcinogens. IARC Cancer Review: Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 21 ,1979,p. 491.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 6 ,1974,p. 135.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.
Safety Profile
Safety Information about  Progesterone (CAS NO.57-83-0):
Hazard Codes: HarmfulXn,ToxicT
Risk Statements: 40-45 
R40: Limited evidence of a carcinogenic effect. 
R45: May cause cancer.
Safety Statements: 36/37-45-53
S36/37: Wear suitable protective clothing and gloves. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53: Avoid exposure - obtain special instructions before use.
WGK Germany: 3
RTECS: TW0175000
Specification

 Progesterone (CAS NO.57-83-0) is also called Progestin ; Lutren ; Lutein ; Flavolutan ; Corporin ; Luteal hormone ; 4-Pregnene-3,20-dione .

Progesterone Basic information

  • Product Name:

    Progesterone

  • CAS No:57-83-0
  • Formula:C21H30O2
  • Molecular Structure:Molecular Structure of (<span class=bigs><a href=/cas-57/57-83-0.html />57-83-0</a></span>) (Progesterone)
  • Synonyms:Luteosan;Luteostab;Luteovis;Luteum;Lutex;Lutidon;Lutin;Lutociclina;Lutocuclin M;Lutocyclin;Lutocyclin M;Lutocylin;Lutoform;Lutogyl;Lutren;Lutromone;Microgest;Minagest;NSC 64377;NSC 9704;Nalutron;Percutacrine Luteinique;Piaponon;Primolut;Prochieve;Progeffik;Progekan;Progestan;Progestasert;Progesterol;Progestin;Progestogel;Progestol;Progeston;Progestone;Progestron;Prolets;Prolidon;Proluton;Prometrium;Prontogest;Protormone;Syngesterone;Syngestrets;Syntolutan;U 3672;Utrogest;Utrogestan;Vitarrine;D4-Pregnene-3,20-dione;Progesterone (Micro & Wettable);Natural Micronised Progesterone;Progesterone(8CI);Agolutin;Bio-luton;CIDR;Corlutin;Corlutina;Corluvite;Corporin;Corpus luteum hormone;Crinone;Cyclogest;Duraprogen;Endometrin;Estima;Flavolutan;Fologenon;Gesterol;Gestiron;Gestone;Gestormone;Gestron;Glanducorpin;Gynlutin;Gynolutone;Hormoflaveine;Hormoluton;Lipo-Lutin;Lucorteum Sol;Lugesteron;Lugesterone;Luteal Hormone;Luteinique;Luteocrinnormale;Luteodyn;Luteogan;Luteohormone;Luteol;Luteopur;Pregn-4-ene-3,20-dione;
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