Basic information
- Name:
Progesterone
- CAS No.:
57-83-0
- Molecular Structure:
- Formula:
- C21H30O2
- Synonyms:
- Luteosan;Luteostab;Luteovis;Luteum;Lutex;Lutidon;Lutociclina;Lutocylin;Lutoform;Lutren;Lutromone;NSC 64377;NSC 9704;Prochieve;Progekan;Progestan;Progestasert;Progestogel;Progestol;Progestone;Prolidon;Prontogest;Syntolutan;Utrogest;Utrogestan;Vitarrine;D4-Pregnene-3,20-dione;Natural Micronised Progesterone;Progesterone(8CI);Agolutin;Corluvite;Corporin;Corpus luteum hormone;Crinone;Cyclogest;Duraprogen;Flavolutan;Fologenon;Gestiron;Gestormone;Gestron;Glanducorpin;Gynlutin;Gynolutone;Hormoflaveine;Lugesterone;Luteal Hormone;Luteinique;Luteodyn;Luteogan;Luteopur;Pregn-4-ene-3,20-dione;
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*Required Fields
Chemistry
Molecular Structure:
Molecular Formula: C21H30O2
Molecular Weight: 314.46
CAS NO: 57-83-0
EINECS: 200-350-6
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 1
Polar Surface Area: 34.14 Å2
Index of Refraction: 1.542
Molar Refractivity: 90.95 cm3
Molar Volume: 288.9 cm3
Surface Tension: 41.1 dyne/cm
Density: 1.08 g/cm3
Flash Point: 166.7 °C
Enthalpy of Vaporization: 70.54 kJ/mol
Boiling Point: 447.2 °C at 760 mmHg
Vapour Pressure: 3.44E-08 mmHg at 25°C
Melting point: 128-132 °C(lit.)
Alpha: 186 º (c=1, ethanol)
Solubility: H2O: 25 mg/mL, may be clear to slightly hazy
Appearance: Crystalline Powder
Stability: Stable. Incompatible with strong oxidizing agents.
IUPAC Name: (8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-
dodecahydrocyclopenta[a]phenanthren-3-one
Product Categories of Progesterone (CAS NO.57-83-0): MI;FINISHED MEDICINE;Steroids;ketone;Biochemistry;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor
Uses
Progesterone (CAS NO.57-83-0) and its analogues have many medical applications, both to address acute situations and to address the long-term decline of natural progesterone levels.
Production
Biosynthesis of Progesterone (CAS NO.57-83-0) :
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Laboratory Synthesis of Progesterone (CAS NO.57-83-0):
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Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LDLo | intravenous | 100mg/kg (100mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. |
| rat | LD50 | intraperitoneal | 327mg/kg (327mg/kg) | Drugs in Japan Vol. -, Pg. 1183, 1995. |
Consensus Reports
Safety Profile
Hazard Codes:
Xn,
T Risk Statements: 40-45
R40: Limited evidence of a carcinogenic effect.
R45: May cause cancer.
Safety Statements: 36/37-45-53
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53: Avoid exposure - obtain special instructions before use.
WGK Germany: 3
RTECS: TW0175000
Specification
Progesterone (CAS NO.57-83-0) is also called Progestin ; Lutren ; Lutein ; Flavolutan ; Corporin ; Luteal hormone ; 4-Pregnene-3,20-dione .
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